In recent years cocrystal formation has emerged as a viable strategy towards improving the
solubility and bioavailability of poorly soluble drugs. In this review the success of numerous …

Phase transformation of an active pharmaceutical ingredient in the solid state can influence
the physicochemical properties and consequently drug product performance. The neat …

Multicomponent crystals such as co-crystals, salts, and solid solutions can be used to modify
physical properties of active pharmaceutical ingredients. Phase diagrams of such …

Crystallization is an important unit operation in pharmaceutical drug substance
manufacturing for the isolation of organic products. Impurity control is a recurring critical …

Drug stability plays a significant role in the pharmaceutical industry from early-phase drug
discovery to product registration as well as the entire life cycle of a product. Various …

Introduction: Pharmaceutical cocrystallization has emerged in the past decade as a new
strategy to enhance the clinical performance of orally administered drugs. A pharmaceutical …

A methodology has been developed to determine the design space of caffeine–glutaric acid
co-crystallization for process development and scale-up. Polymorphic purity is chosen as a …

Cocrystallization is an extensively used method in Crystal Engineering for tuning the
properties of target compounds by pairing them with ad-hoc selected molecular partners (ie …

A 96-well high-throughput cocrystal screening workflow has been developed consisting of
solvent-mediated sonic blending synthesis and on-plate solid/solution stability …

Poor aqueous solubility of a majority of new small molecule chemical entities is a significant
challenge in drug discovery since considerably high exposures are often required to enable …