Objectives To assess the effect of antihypertensive treatment in the 130–140 mm Hg systolic
blood pressure range. Design Systematic review and meta-analysis. Information sources …

Background The benefits of blood pressure lowering treatment for prevention of
cardiovascular disease are well established. However, the extent to which these effects …

BACKGROUND: Previous meta-analyses resurrected the debated statement “the lower, the
better” following blood pressure (BP)-lowering treatment. We investigated the benefits of BP …

Background The effects of pharmacological blood pressure lowering at normal or high-
normal blood pressure ranges in people with or without pre-existing cardiovascular disease …

Methods This meta-analysis included BP-lowering treatment trials (vs placebo or each other
with different BP targets) on all-cause mortality, CVD mortality, major cardiovascular events …

Background The benefits of reducing blood pressure are well established, but there remains
uncertainty about whether the magnitude of the effect varies with the initial blood pressure …

Background: Randomized controlled trials (RCTs) of blood pressure (BP) lowering lend
themselves to be meta-analyzed to help providing evidence-based recommendations for …

Importance High blood pressure (BP) is the most important risk factor for death and
cardiovascular disease (CVD) worldwide. The optimal cutoff for treatment of high BP is …

Current European guidelines for the management of hypertension and on cardiovascular
disease prevention place the threshold for pharmacological treatment at a SBP level of 140 …

Abstract Purpose of Review To review the recent large-scale randomised evidence on
pharmacologic reduction in blood pressure for the primary and secondary prevention of …