Antisense Inhibition of Angiotensinogen With IONIS-AGT-LRx Results of Phase 1 and Phase 2 Studies
ES Morgan, Y Tami, K Hu, M Brambatti… - Basic to Translational …, 2021 - jacc.org
Targeting angiotensinogen (AGT) may provide a novel approach to more optimally inhibit
the renin-angiotensin-aldosterone system pathway. Double-blind, placebo-controlled …
the renin-angiotensin-aldosterone system pathway. Double-blind, placebo-controlled …
Blood pressure lowering and safety improvements with liver angiotensinogen inhibition in models of hypertension and kidney injury
AE Mullick, ST Yeh, MJ Graham, JA Engelhardt… - …, 2017 - Am Heart Assoc
Uncontrolled hypertension is an important contributor to cardiovascular disease. Despite the
armamentarium of antihypertensive treatments, there remains a need for novel agents …
armamentarium of antihypertensive treatments, there remains a need for novel agents …
Antisense oligonucleotides targeting angiotensinogen: insights from animal studies
CH Wu, Y Wang, M Ma, AE Mullick… - Bioscience …, 2019 - portlandpress.com
Angiotensinogen (AGT) is the unique substrate of all angiotensin peptides. We review the
recent preclinical research of AGT antisense oligonucleotides (ASOs), a rapidly evolving …
recent preclinical research of AGT antisense oligonucleotides (ASOs), a rapidly evolving …
Angiotensinogen suppression: a new tool to treat cardiovascular and renal disease
Multiple types of renin-angiotensin system (RAS) blockers exist, allowing interference with
the system at the level of renin, angiotensin-converting enzyme, or the angiotensin II …
the system at the level of renin, angiotensin-converting enzyme, or the angiotensin II …
Targeting Angiotensinogen With N-Acetylgalactosamine–Conjugated Small Interfering RNA to Reduce Blood Pressure
Blood pressure management involves antihypertensive therapies blocking the renin-
angiotensin system (RAS). Yet, it might be inadequate due to poor patient adherence or the …
angiotensin system (RAS). Yet, it might be inadequate due to poor patient adherence or the …
Targeting of the renin-angiotensin system by antisense gene therapy: a possible strategy for the long-term control of hypertension
MK Raizada, SC Francis, H Wang… - Journal of …, 2000 - journals.lww.com
Traditional pharmacological agents have been successfully used for the treatment of
hypertension for a number of decades. However, this therapeutic regimen has reached a …
hypertension for a number of decades. However, this therapeutic regimen has reached a …
Targeting angiotensinogen with RNA-based therapeutics
L Ren, KMM Colafella, DM Bovee, E Uijl… - Current Opinion in …, 2020 - journals.lww.com
Targeting angiotensinogen with RNA-based therapeutics is a promising new tool to treat
hypertension and diseases beyond. Their long-lasting effects are particularly exciting, and if …
hypertension and diseases beyond. Their long-lasting effects are particularly exciting, and if …
Angiotensinogen: more than its downstream products: evidence from population studies and novel therapeutics
T Kahlon, S Carlisle, D Otero Mostacero, N Williams… - Heart Failure, 2022 - jacc.org
The renin-angiotensin-aldosterone system (RAAS) is a well-defined pathway playing a key
role in maintaining circulatory homeostasis. Abnormal activation of RAAS contributes to …
role in maintaining circulatory homeostasis. Abnormal activation of RAAS contributes to …
Angiotensin I–converting enzyme antisense gene therapy causes permanent antihypertensive effects in the SHR
H Wang, PY Reaves, ML Gardon, K Keene… - …, 2000 - Am Heart Assoc
The renin-angiotensin system plays a critical role in the control of blood pressure (BP), and
its hyperactivity is associated with the development and maintenance of hypertension …
its hyperactivity is associated with the development and maintenance of hypertension …
Strong and sustained antihypertensive effect of small interfering RNA targeting liver angiotensinogen
E Uijl, KM Mirabito Colafella, Y Sun, L Ren… - …, 2019 - Am Heart Assoc
Small interfering RNAs (siRNAs) targeting hepatic angiotensinogen (Agt) may provide long-
lasting antihypertensive effects, but the optimal approach remains unclear. Here, we …
lasting antihypertensive effects, but the optimal approach remains unclear. Here, we …