The greatest limitation in the development of transdermal drug delivery systems is that only a
few drugs can permeate the skin due to the barrier function of the stratum corneum. Active …

A microneedle (MN) is a micron-sized needle with a height of 10–2000 μm and a width of 10–
50 μm, which can penetrate through the epidermis layer to dermal tissue directly without …

Transdermal delivery provides numerous benefits over conventional routes of
administration. However, this strategy is generally limited to a few molecules with specific …

Transdermal route has been explored for various agents due to its advantage of bypassing
the first pass effect and sustained release of drug. Due to strong barrier properties of the …

Transdermal drug delivery has exhaustively been studied over the past decades due to its
multiple advantages over other administration routes; however, drugs that can be …

The skin is the largest and most accessible organ in the human body and, as such, it
appears as the most convenient portal for drug delivery. However, the skin is also a …

Transdermal delivery of drugs offers an interesting alternative for the administration of
molecules that present certain troubles when delivered by the oral route. It can produce …

The transdermal route of drug delivery is convenient, pain-free and follows controlled rate
release pattern. However, many therapeutically active drugs cannot cross the stratum …

Drug delivery through the skin offers many advantages such as avoidance of hepatic first-
pass metabolism, maintenance of steady plasma concentration, safety, and compliance over …

The most widely used methods for transdermal administration of the drugs are hypodermic
needles, topical creams, and transdermal patches. The effect of most of the therapeutic …