Surfactant protein A (SP-A) constitutes an important part of the innate immune defense in the
lung. In humans there are two functional genes (SP-A1 and SP-A2). The functional …

The objective of this study was to determine the effects of proline hydroxylation in the
collagen-like domain and Asn187-linked glycosylation in the globular domain on the …

SP-A (surfactant protein A) is a membrane-associated SP that helps to maintain the lung in a
sterile and non-inflamed state. Unlike SP-As from other mammalian species, human SP-A …

Surfactant protein A (SP-A) is a highly ordered, oligomeric glycoprotein that is secreted into
the airspaces of the lung by the pulmonary epithelium. The in vitro activities of protein …

Four “core” amino acid differences within the collagen-like domain distinguish the human
surfactant protein A1 (SP-A1) variants from the SP-A2 variants. One of these, cysteine 85 …

The role of the degree of oligomerization in the structure and function of human surfactant
protein A (SP-A) was investigated using a human SP-A1 mutant (SP-A1 ΔAVC, C6S) …

Surfactant protein A (SP-A) is the most abundant protein component of lung surfactant, a
complex mixture of proteins and lipids. SP-A performs host defense activities and modulates …

The pulmonary surfactant-associated protein SP-Ais encoded by presumably two different
genes, resulting in slightly different amino acid sequences. Both gene products were …

Background Lung surfactant protein A (SP-A) is a complex molecule composed of up to 18
polypeptide chains. In vivo, SP-A probably binds to a wide range of inhaled materials via the …

Surfactant associated protein-A (SP-A) is the most abundant pulmonary surfactant protein
and belongs to the family of innate host defense proteins termed collectins. Besides …