Addiction involves a predominance of habitual control mediated through action selection
processes in dorsal striatum. Research has largely focused on neural mechanisms …

Everyday function demands efficient and flexible decision-making that allows for habitual
and goal-directed action control. An inability to shift has been implicated in disorders with …

Drug addictions including alcoholism are characterized by degradation of executive control
over behavior and increased compulsive drug seeking. These profound behavioral changes …

A key feature of compulsive alcohol drinking is continuing to drink despite negative
consequences. To examine the changes in neural activity that underlie this behavior …

The acquisition of drug, including alcohol, use is associated with activation of the
mesolimbic dopamine system. However, over the course of drug exposure the control over …

The orbitofrontal cortex (o PFC) sends substantial projections to the ventrolateral striatum
and aspects of the nucleus accumbens that are, functionally, poorly understood. This is …

What individual differences in neural activity predict the future escalation of alcohol drinking
from casual to compulsive? The neurobiological mechanisms that gate the transition from …

Context can influence reactions to environmental cues and this elemental process has
implications for substance use disorder. Using an animal model, we show that an alcohol …

Addiction is proposed to arise from alterations in synaptic strength via mechanisms of long-
term potentiation (LTP) and depression (LTD). However, the causality between these …

Addiction is characterized by a persistent loss of behavioral control resulting in insensitivity
to negative feedback and abnormal decision‐making. Here, we investigated the influence of …