Broad and potent bispecific neutralizing antibody gene delivery using adeno-associated viral vectors for passive immunization against HIV-1
S Li, Y Qiao, S Jiang, B Wang, W Kong… - Journal of Controlled …, 2021 - Elsevier
Broadly neutralizing antibodies (bNAbs) possess favorable safety, and passive
immunization using these can prevent or control human immunodeficiency virus type 1 (HIV …
immunization using these can prevent or control human immunodeficiency virus type 1 (HIV …
[HTML][HTML] Discovery medicine–the HVTN's iterative approach to developing an HIV-1 broadly neutralizing vaccine
TM Martin, ST Robinson, Y Huang - Current Opinion in HIV and …, 2023 - journals.lww.com
In the past two decades, there has been an explosion in the discovery of HIV-1 broadly
neutralizing antibodies (bnAbs) and associated vaccine strategies to induce them. This …
neutralizing antibodies (bnAbs) and associated vaccine strategies to induce them. This …
[HTML][HTML] Recent progress toward engineering HIV-1-specific neutralizing monoclonal antibodies
M Sun, Y Li, H Zheng, Y Shao - Frontiers in Immunology, 2016 - frontiersin.org
The recent discoveries of broadly potent neutralizing human monoclonal antibodies
represent a new generation of antiretrovirals for the treatment and prophylaxis. Antibodies …
represent a new generation of antiretrovirals for the treatment and prophylaxis. Antibodies …
Role of immune mechanisms in induction of HIV-1 broadly neutralizing antibodies
Although antibodies can be elicited by HIV-1 infection or immunization, those that are
broadly neutralizing (bnAbs) are undetectable in most individuals, and when they do arise in …
broadly neutralizing (bnAbs) are undetectable in most individuals, and when they do arise in …
A Randomised Clinical Trial of the Safety and Pharmacokinetics of VRC07-523LS Administered via Different Routes and Doses (HVTN 127/HPTN 087)
SR Walsh, CL Gay, ST Karuna, O Hyrien, T Skalland… - medRxiv, 2024 - medrxiv.org
Background: Broadly neutralizing antibodies (bnAbs) are a promising approach for HIV-1
prevention. In the only bnAb HIV prevention efficacy studies to date, the Antibody Mediated …
prevention. In the only bnAb HIV prevention efficacy studies to date, the Antibody Mediated …
[HTML][HTML] Antibodies and antibody derivatives: new partners in HIV eradication strategies
Promptly after primoinfection, HIV generates a pool of infected cells carrying transcriptionally
silent integrated proviral DNA, the HIV-1 reservoir. These cells are not cleared by combined …
silent integrated proviral DNA, the HIV-1 reservoir. These cells are not cleared by combined …
[PDF][PDF] The AMP trials—a glass half full
BD Walker - N Engl J Med, 2021 - corevih-bretagne.fr
Induction of broadly neutralizing antibodies (bnAbs) is considered the holy grail for a
preventive human immunodeficiency virus (HIV) vaccine, but four decades into the HIV …
preventive human immunodeficiency virus (HIV) vaccine, but four decades into the HIV …
[HTML][HTML] Bispecific anti-HIV-1 antibodies with enhanced breadth and potency
S Bournazos, A Gazumyan, MS Seaman… - Cell, 2016 - cell.com
Broadly neutralizing antibodies (bNAbs) against the HIV-1 envelope glycoprotein (Env)
suppress viremia in animal models of HIV-1 and humans. To achieve potent activity without …
suppress viremia in animal models of HIV-1 and humans. To achieve potent activity without …
[PDF][PDF] Journal of Virus Eradication
The use of broadly neutralizing antibodies (bNAbs) as a cure-related research strategy for
human immunodeficiency virus (HIV) has gained attention from the scientific community …
human immunodeficiency virus (HIV) has gained attention from the scientific community …
[HTML][HTML] Antiviral activities of HIV-1-Specific human broadly neutralizing antibodies are isotype-dependent
B Noailly, M Yaugel-Novoa, J Werquin, F Jospin… - Vaccines, 2022 - mdpi.com
Broadly neutralizing antibodies (bNAbs) offer promising opportunities for preventing HIV-1
infection. The protection mechanisms of bNAbs involve the Fc domain, as well as their Fab …
infection. The protection mechanisms of bNAbs involve the Fc domain, as well as their Fab …