[HTML][HTML] Characterization of a human-specific tandem repeat associated with bipolar disorder and schizophrenia
Bipolar disorder (BD) and schizophrenia (SCZ) are highly heritable diseases that affect more
than 3% of individuals worldwide. Genome-wide association studies have strongly and …
than 3% of individuals worldwide. Genome-wide association studies have strongly and …
Case–case genome-wide association analysis shows markers differentially associated with schizophrenia and bipolar disorder and implicates calcium channel genes
D Curtis, AE Vine, A McQuillin, NJ Bass… - Psychiatric …, 2011 - journals.lww.com
Objective There are theoretical reasons why comparing marker allele frequencies between
cases of different diseases, rather than with controls, may offer benefits. The samples may …
cases of different diseases, rather than with controls, may offer benefits. The samples may …
Identification of a CACNA2D4 deletion in late onset bipolar disorder patients and implications for the involvement of voltage‐dependent calcium channels in …
MJ Van Den Bossche, M Strazisar… - American Journal of …, 2012 - Wiley Online Library
The GWAS‐based association of CACNA1C with bipolar disorder (BPD) is one of the
strongest genetic findings to date. CACNA1C belongs to the family of CACN genes …
strongest genetic findings to date. CACNA1C belongs to the family of CACN genes …
CACNA1C hypermethylation is associated with bipolar disorder
A Starnawska, D Demontis, A Pen, A Hedemand… - Translational …, 2016 - nature.com
The CACNA1C gene, encoding a subunit of the L-type voltage-gated calcium channel is one
of the best-supported susceptibility genes for bipolar disorder (BD). Genome-wide …
of the best-supported susceptibility genes for bipolar disorder (BD). Genome-wide …
Functional Characterization of Schizophrenia-Associated Variation in CACNA1C
Calcium channel subunits, including CACNA1C, have been associated with multiple
psychiatric disorders. Specifically, genome wide association studies (GWAS) have …
psychiatric disorders. Specifically, genome wide association studies (GWAS) have …
Genetic variation in CACNA1C affects brain circuitries related to mental illness
Context TheCACNA1Cgene (α-1C subunit of the L-type voltage-gated calcium channel) has
been identified as a risk gene for bipolar disorder and schizophrenia, but the mechanism of …
been identified as a risk gene for bipolar disorder and schizophrenia, but the mechanism of …
Functional implications of a psychiatric risk variant within CACNA1C in induced human neurons
T Yoshimizu, JQ Pan, AE Mungenast, JM Madison… - Molecular …, 2015 - nature.com
Psychiatric disorders have clear heritable risk. Several large-scale genome-wide
association studies have revealed a strong association between susceptibility for psychiatric …
association studies have revealed a strong association between susceptibility for psychiatric …
The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia
Molecular genetic analysis offers opportunities to advance our understanding of the
nosological relationship between psychiatric diagnostic categories in general, and the mood …
nosological relationship between psychiatric diagnostic categories in general, and the mood …
The CACNA1C risk variant for bipolar disorder influences limbic activity
An enhanced limbic activity, particularly in the amygdala, is one of the most consistent
findings in bipolar disorder. Here, we show that healthy carriers of the genome-wide …
findings in bipolar disorder. Here, we show that healthy carriers of the genome-wide …
CACNA1C, schizophrenia and major depressive disorder in the Han Chinese population
Background Common psychiatric disorders are highly heritable, indicating that genetic
factors play an important role in their aetiology. The CACNA1C gene, which codes for …
factors play an important role in their aetiology. The CACNA1C gene, which codes for …