Immune infiltrates in the tumor microenvironment (TME) of breast cancer (BRCA) have been
shown to play a critical role in tumorigenesis, progression, invasion, and therapy resistance …

The tumor microenvironment (TME) is a complex mixture of cell-types that interact with each
other to affect tumor growth and clinical outcomes. To accelerate the discovery of such …

Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer that has few
effective treatment options due to its lack of targetable hormone receptors. Whilst the degree …

Background: De-escalation and escalation of systemic therapy in early-stage TNBC will
require the implementation of biomarkers to guide therapy. To date, high expression of a …

Background: Emerging data suggest that some patients with TNBC could benefit from the
addition of immune-based therapy. This observation is in part due to the significant …

Purpose: Increasing tumor-infiltrating lymphocytes (TIL) is associated with higher rates of
pathologic complete response (pCR) to neoadjuvant therapy (NAT) in patients with triple …

Triple-negative breast cancer (TNBC) is one of the most aggressive breast cancer subtypes
and is characterized by abundant infiltrating immune cells within the microenvironment. As …

Triple negative breast cancer (TNBC) is a heterogenous disease that disproportionately
affects Black women. TNBC outcomes among Black women are dismal secondary to …

Introduction Patients with high-risk, triple negative breast cancer (TNBC) often receive
neoadjuvant chemotherapy (NAC) alone or with immunotherapy. Various single-cell and …

Signaling between cancer and nonmalignant (stromal) cells in the tumor microenvironment
(TME) is key to tumorigenesis yet challenging to decipher from tumor transcriptomes. Here …