Selective androgen receptor modulators (SARMS) bind to the androgen receptor and
demonstrate anabolic activity in a variety of tissues; however, unlike testosterone and other …

Abstract Purpose of Review Prostate cancer is one of the most common cancers in men and
accounts for about 10% of all new cancer cases in the USA. Despite significant …

Hyperandrogenic disorders are frequent in women. The most common cause is polycystic
ovary syndrome, a condition found up to 7% in women of reproductive age. The effects of …

Androgen receptor (AR) is a ligand-activated transcription factor that is the main target for
treatment of non-organ-confined prostate cancer (CaP). Failure of life-prolonging AR …

Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor
Modulator (SARM) RAD140 | ACS Medicinal Chemistry Letters ACS ACS Publications C&EN …

Background/Aim: Prostate cancer is one of the most common cancers in men which remains
a global public health issue. Treatment of prostate cancer is becoming increasingly intensive …

Our previous study revealed that Epimedii Folium (EF) and Codonopsis Radix (CNR)
significantly promoted tumor growth on a subcutaneous mouse model of prostate cancer …

Introduction: Androgen receptor (AR) antagonists are predominantly used as chemical
castration to treat prostate cancer (ie, in conjunction with androgen deprivation therapy …

BACKGROUND To identify the phytoandrogen from phytohormone, we established an
assay to assess the androgenicity of phytoestrogens by using androgen receptor (AR) …

We have found that in addition to being potent inhibitors of 17α-hydroxylase/C17, 20-lyase
and/or 5α-reductase, some of our novel androgen synthesis inhibitors also interact with the …