Explainable Machine Learning Reveals the Role of the Breast Tumor Microenvironment in Neoadjuvant Chemotherapy Outcome
Recent advancements in single-cell RNA sequencing (scRNA-seq) have enabled the
identification of phenotypic diversity within breast tumor tissues. However, the contribution of …
identification of phenotypic diversity within breast tumor tissues. However, the contribution of …
The expression patterns of different cell types and their interactions in the tumor microenvironment are predictive of breast cancer patient response to neoadjuvant …
SR Dhruba, S Sahni, B Wang, D Wu, PS Rajagopal… - bioRxiv, 2024 - biorxiv.org
The tumor microenvironment (TME) is a complex ecosystem of diverse cell types whose
interactions govern tumor growth and clinical outcome. While the TME's impact on …
interactions govern tumor growth and clinical outcome. While the TME's impact on …
Abstract LB_A02: Predicting breast cancer patients' response to neoadjuvant chemotherapy from the deconvolved transcriptome of different cell types in the tumor …
Introduction: The tumor microenvironment (TME) constitutes a multifaceted ecosystem that
influences tumor growth and clinical response via dynamic interactions between diverse cell …
influences tumor growth and clinical response via dynamic interactions between diverse cell …
The expression patterns of different cell types and their interactions in the tumor microenvironment are predictive of breast cancer patient response to neoadjuvant …
The tumor microenvironment (TME) is a complex ecosystem of diverse cell types whose
interactions govern tumor growth and clinical outcome. While the TME's impact on …
interactions govern tumor growth and clinical outcome. While the TME's impact on …
Abstract LB242: Prediction of patient response to neoadjuvant chemotherapy in breast cancer from their deconvolved tumor microenvironment transcriptome
Introduction: The tumor microenvironment (TME) is a complex and dynamic ecosystem that
plays critical roles in tumor development and clinical outcome. While the multifarious cellular …
plays critical roles in tumor development and clinical outcome. While the multifarious cellular …
Integrated single-cell and bulk RNA sequencing analysis identifies the predictive signature for prognosis and neoadjuvant chemotherapy responses in breast cancer
R Feng, J Guo, L Pan, Y Yao, J Gao, X Zhang - 2023 - researchsquare.com
Neoadjuvant chemotherapy (NAC) is a well-established treatment modality for locally
advanced breast cancer (BC). However, it can also result in severe toxicities while …
advanced breast cancer (BC). However, it can also result in severe toxicities while …
Genomic and transcriptomic analysis of breast cancer identifies novel signatures associated with response to neoadjuvant chemotherapy
G Yin, L Liu, T Yu, L Yu, M Feng, C Zhou, X Wang… - Genome Medicine, 2024 - Springer
Background Neoadjuvant chemotherapy (NAC) has become a standard treatment strategy
for breast cancer (BC). However, owing to the high heterogeneity of these tumors, it is …
for breast cancer (BC). However, owing to the high heterogeneity of these tumors, it is …
Integrated single-cell and bulk RNA sequencing analysis identifies a neoadjuvant chemotherapy-related gene signature for predicting survival and therapy in breast …
X Zhang, R Feng, J Guo, L Pan, Y Yao, J Gao - BMC Medical Genomics, 2023 - Springer
Neoadjuvant chemotherapy (NAC) is a well-established treatment modality for locally
advanced breast cancer (BC). However, it can also result in severe toxicities while …
advanced breast cancer (BC). However, it can also result in severe toxicities while …
The Breast Cancer Single-Cell Atlas: Defining cellular heterogeneity within model cell lines and primary tumors to inform disease subtype, stemness, and treatment …
Abstract Purpose Breast Cancer (BC) is the most diagnosed cancer in women; however,
through significant research, relative survival rates have significantly improved. Despite …
through significant research, relative survival rates have significantly improved. Despite …
Chemotherapy induces dynamic immune responses in breast cancers that impact treatment outcome
To elucidate the effects of neoadjuvant chemotherapy (NAC), we conduct whole
transcriptome profiling coupled with histopathology analyses of a longitudinal breast cancer …
transcriptome profiling coupled with histopathology analyses of a longitudinal breast cancer …
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