Genome-wide CRISPR/Cas9 Screens Reveal Shared and Bespoke Mechanisms of Resistance to SHP2 inhibition

W Wei - 2023 - search.proquest.com
Abstract SHP2 (PTPN11) acts upstream of SOS1/2 to enable RAS activation. Allosteric
SHP2 inhibitors (SHP2i) in the clinic prevent SHP2 activation, block proliferation of RTK-or …
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Genome-wide CRISPR/Cas9 Screens Reveal Shared and Bespoke Mechanisms of Resistance to SHP2 inhibition

W Wei, MJ Geer, X Guo, I Dolgalev, NE Sanjana… - 2022 - europepmc.org
SHP2 (PTPN11) acts upstream of SOS1/2 to enable RAS activation. Allosteric inhibitors
(SHP2is) stabilize SHP2 auto-inhibition, preventing activation by upstream stimuli. SHP2is …
[PDF] archive.org

[PDF][PDF] Genome-wide CRISPR/Cas9 Screens Reveal Shared and Bespoke Mechanisms of Resistance to SHP2 inhibition

W Wei, MJ Geer, X Guo, I Dolgalev, NE Sanjana… - scholar.archive.org
Abstract SHP2 (PTPN11) acts upstream of SOS1/2 to enable RAS activation. Allosteric
inhibitors (SHP2is) stabilize SHP2 auto-inhibition, preventing activation by upstream stimuli …

Genome-wide CRISPR/Cas9 Screens Reveal Shared and Bespoke Mechanisms of Resistance to SHP2 inhibition

W Wei, MJ Geer, X Guo, I Dolgalev, NE Sanjana… - bioRxiv, 2022 - biorxiv.org
Abstract SHP2 (PTPN11) acts upstream of SOS1/2 to enable RAS activation. Allosteric
inhibitors (SHP2is) stabilize SHP2 auto-inhibition, preventing activation by upstream stimuli …