… a PG (12)-based PROTAC, SJ10542, with highly selective JAK … a selective degrader of
HDAC3 with a submicromolar activity … 31 showed a powerful anticancer activity in breast, ovarian, …

… potential as a PROTAC in effectively and selectively degrading … levels and demonstrated
strong antitumor activity in mice … targeted a band region on BCL-xL for ubiquitination, indicating …

… of an orally active PROTAC AR degrader for the treatment of … , the design of PROTAC degraders
to achieve excellent oral … strategies toward discovering potent PROTAC degraders of AR …

… The same research group also carried out a series of experiments for the design of the most
effective mAb-PROTAC conjugates using BRD4-degrading PROTACs [99,100]. They have …

… trials in 2019 and achieved satisfactory safety and efficacy … A05 exhibited the most potent
antitumor activity with an IC 50 … In summary, by introducing different PROTAC substitutions at …

… PROTAC technology achieves targeted protein degradation … of PROTAC technology, molecular
glue technology, degrader-… exhibited minimal degradation of BCL-XL in platelets, and in …

… PROTAC prodrug-based nanomedicine to improve PROTAC … ha-PROTAC behaved potent
EGFR-degrading activity in a … to activate the PROTAC prodrugs and achieve precise protein …

… -E3” complex and is sufficient to achieve appropriate … the ability of a PROTAC to degrade
the targeted protein [84]. The … -based BCL-XL PROTAC XZ739 showed 20 times more potency …

… PROTACs drive POIs into the UPS degrading system by … fact that both sites achieved similar
PROTAC exposure. Perhaps … latter effect was paralleled by a significant reduction in Bcl-xL …

… -PROTAC conjugate could achieve targeted antitumor activity … E3 ligases and still degrade
nucleolin. PROTACs promote … PROTAC to degrade its target are questions that need further …