… This review focuses on the synthetic accessibility and potential for library synthesis of … Within
this review, heterocyclic compounds acting as GABA A receptor modulators will be revised. …

… selectivity exists within a given chemotype, generally it is quite “… a range of different heterocyclic
cores decorated with … ; Kooy, RF The complexity of the GABAA receptor shapes unique …

… by a five-membered heterocyclic scaffold functionalized with amide … structural changes of a
given allosteric chemotype. Thus, during … Nature Reviews Drug Discovery, 13, 692–708 and …

… (PAMs) and α5-GABA A R negative allosteric modulators (… heterocyclic cores (series 1–3,
Figure 4). The imidazopyridazine series (series 2) was selected as the preferred chemotype …

… Most chemotypes comprise positive allosteric modulators (… we report the results of our study
on a new series of GABA A R … by sulfur-containing heterocycles was successfully used for the …

… [1,5-a]pyrazinone chemotype which was consistently … chemotypes discussed in this review.
For instance, 20 of the 21 patent applications centered on scaffolds with a fused heterocyclic …

… compounds from within the broad disubstituted alkyne chemotype. An application from Merz
describes a series of heterocyclic analogs where one of the groups bound to the alkyne is a …

… review highlights the discovery of representative allosteric … serious side effects, several
chemotypes of AMPAR NAMs have been … of allosteric modulators targeting GABA A receptors. …

… Accordingly, this review aims to summarize the current … of GABA A Rs, as well as shedding
light on the most common … , silent allosteric modulators (SAM) are a class of GABA A R …

… , but also the group II and group III allosteric modulators and … the exploration of 6-substituted
chemotypes, with an EC 50 … on a five-membered heterocyclic group and found sulfone …