[HTML][HTML] An engineered orco mutation produces aberrant social behavior and defective neural development in ants

H Yan, C Opachaloemphan, G Mancini, H Yang… - Cell, 2017 - cell.com
orco mutations should significantly impact olfaction. We demonstrate striking functions of
Orco in odorant perception, reproductive physiology, and social behavior plasticity. Surprisingly…

[HTML][HTML] Orco mutagenesis causes loss of antennal lobe glomeruli and impaired social behavior in ants

W Trible, L Olivos-Cisneros, SK McKenzie, J Saragosti… - Cell, 2017 - cell.com
… in general olfactory behaviors. These ants also have deficiencies in social behavior, including
… insects, we also find that orco mutant ants possess striking neuro-anatomical phenotypes, …

Neurodevelopmental and transcriptomic effects of CRISPR/Cas9-induced somatic orco mutation in honey bees

Z Chen, IM Traniello, S Rana… - Journal of …, 2021 - Taylor & Francis
… , an important model system for social behavior and chemical … After observing the antennal
lobe defects reported above, we … Such complicated evolution history makes it difficult to give a …

Olfactory receptors are required for social behavior and neural plasticity in ants, as evidenced by CRISPR-mediated gene knockout

H Yan, C Opachaloemphan, G Mancini, H Yang… - BioRxiv, 2017 - biorxiv.org
… (leaving the colony to forage), most likely due to a defect in sensing … To address whether the
orco mutation affected dueling and the … This aberrant behavior is paradoxical given that the …

[HTML][HTML] Mutagenesis of the odorant receptor co-receptor (Orco) reveals severe olfactory defects in the crop pest moth Helicoverpa armigera

XB Fan, BT Mo, GC Li, LQ Huang, H Guo, XL Gong… - BMC biology, 2022 - Springer
… Moreover, we examined the behaviors of their adults and larvae… inferred to produce a
nonfunctional, truncated Orco protein … these Ors from cell body to neuronal dendrites in H. …

[HTML][HTML] New tools, new insights—probing social behaviour in ants

D Clyde - Nature Reviews Genetics, 2017 - nature.com
… lobes of the brain was dramatically reduced in orco mutant ants, as … orco mutants, which
points to a possible role for orco in … the diverse social systems within ant species, makes them …

Orco-dependent survival of odorant receptor neurons in ants

B Sieriebriennikov, KR Sieber, O Kolumba… - Science …, 2024 - science.org
… in antennal ORNs in adult orco mutant ants, we performed … as long as they additionally
produced a functional IR/Irco … mechanism underlying their defective neural development. …

[HTML][HTML] Disruption of the odorant coreceptor Orco impairs foraging and host finding behaviors in the New World screwworm fly

DF Paulo, ACM Junqueira, AP Arp, AS Vieira… - Scientific Reports, 2021 - nature.com
… Out of the ten selected G 0 putative founders, nine produced … to rescue functional defects
in Orco mutants of Drosophila, … -classical model insects, including social behavior in ants 34 , …

Mutagenesis of odorant coreceptor Orco fully disrupts foraging but not oviposition behaviors in the hawkmoth Manduca sexta

RA Fandino, A Haverkamp… - Proceedings of the …, 2019 - National Acad Sciences
mutation 1, facilitating the identification of the KO allele. Individuals with the Orco KO allele
produced … of the MsexOrco mutation, we analyzed antennal and brain responses to the sex …

Mutagenesis of the orco odorant receptor co-receptor impairs olfactory function in the malaria vector Anopheles coluzzii

H Sun, F Liu, Z Ye, A Baker, LJ Zwiebel - Insect biochemistry and molecular …, 2020 - Elsevier
… -dependent pathways, we designed a simple two-choice behavioral bioassay to test the … is
required for neuronal physiology as well as a range of downstream olfactory-driven behaviors. …