… of resorcylate natural products to produce fungal-selective compounds, we have … synthetic
aminopyrazole-substituted resorcylate amides with broad, potent, and fungal-selective Hsp90 …

… in our pursuit of fungal-selective, resorcylate inhibitors of the protein-folding chaperone
Hsp90, and building on early leads from our prior study of resorcylate aminopyrazoles (RAPs), …

… Ongoing efforts towards obtaining co-crystals with our novel resorcylate aminopyrazole …
and guiding structure-based efforts in development of fungal-selective Hsp90 inhibitors. …

… (17) A recent study focusing on the Hsp90 nucleotide-binding domain (NBD) of C. albicans
… -selective Hsp90 inhibitors based on semisynthetic oxime derivatization of the resorcylate …

… with thiopyrazine based fungal selective HSP90 inhibitors, increasing the absorption of …
Preparation of resorcylate aminopyrazole compounds as Hsp90 inhibitors and uses thereof …

… upstream regulators of Hsp90 function or downstream … The discovery of species-selective
Hsp90 inhibitors, which is … fungal-selective inhibition by targeting the function of Hsp90 …

… Marcyk et al. published in 2021 the x-ray crystallographic structures of three fungal selective
Hsp90 inhibitors, namely resorcylate aminopyrazoles (RAPs), in complex with the nucleotide…

… pan-inhibitors of Hsp90 based on the classification of binding sites and illustrated design
strategies … We summed up current isoform-specific Hsp90 inhibitors including their discovery …

… NBDs enabled the synthesis of fungal-selective Hsp90 inhibitors. … identified as a selective
Hsp90 inhibitor with an inhibitory … A series of synthetic resorcylate aminopyrazoles (RAPs) with …

… generation of Hsp90/HDAC dual inhibitors were designed as … J5 exhibited fungal-selective
inhibitory effects on Hsp90 and … due to the fungal-selective inhibition on Hsp90 and HDACs. …