… for understanding fetal and placental cholesterol management. … lysosomal and mitochondrial
dysfunction. This review discusses the role of cholesterol, lysosomal and mitochondrial …

… been demonstrated that the human placenta requires more than 1 g of cholesterol for
tissue … After receptor-mediated uptake of LDL, the particle is transported to the lysosome/endosome …

… We will then address mechanisms of cholesterol transport … putative contact sites between
lysosomes and mitochondria (D). B) … , the mitochondrial targeting sequence serves to focus the …

… In this review we focus on the mitochondrial adaptions and … The importance of
mitochondria and intracellular signaling … of mitochondrial protein and subsequent lysosomal …

… in cholesterol transport from late endosomes to mitochondria. … late endosome markers
lysosome-associated membrane … endosome and mitochondria in human placental cells. The …

… protein-mediated cholesterol transport to the mitochondria, and … human placental cell line)
is reduced, cholesterol flux into … various intracellular organelles, including lysosomes and lipid …

… They fuse with lysosomes and then degraded by the lysosomal … of intracellular ROS
generated by mitochondria [75], and … Infusion of TCA using ex vivo–perfused human placental …

… date, their importance for lysosomal biogenesis during human placental development and
… of organelles and autophagy) and mainly focused on extravillous trophoblasts while we …

… and systemic cholesterol metabolism in non-placental cells, the … the current knowledge of
the receptor in the human placenta. … free cholesterol that is exported by the lysosomal proteins …

… intracellular transport pathway of LDL–LDLR bypasses the lysosomes and delivers cholesterol
to the mitochondria … , we performed a small-scale RNA interference screen focusing on …