IFNγ facilitates liver fibrogenesis by CD161+CD4+ T cells through a regenerative IL23/IL‐17 axis in chronic hepatitis B virus infection

…, H Jia, C Liu, S Wang, Y Liu, Y Shen… - Clinical & …, 2021 - Wiley Online Library
… of circulating CD161 + CD4 + T cells in liver fibrosis were … the well-established genes in liver
fibrogenesis, including α-SMA, … regenerative IFN-γ/IL-23/IL-17 axis between CD161 + CD4 + …

IL-23 mediates murine liver transplantation ischemia-reperfusion injury via IFN-γ/IRF-1 pathway

JR Klune, C Bartels, J Luo, S Yokota… - … and Liver …, 2018 - journals.physiology.org
IL-23 acts on CD4 + T cells to cause differentiation into T … and liver damage, whereas IL-23
promotes IFN-γ production … ) on these liver sections for the NKT cell marker CD161. We found …

γδ T cells in liver diseases

X Wang, Z Tian - Frontiers of medicine, 2018 - Springer
… and cirrhosis, and liver cancer and regeneration. In this study, … , IL-17A-producing CD161+
γδ T cells are enriched in the … -γδ T cells-IL-17A/IL-22 axis promotes liver regeneration. These …

Alterations in intestinal microbiota lead to production of interleukin 17 by intrahepatic γδ T-cell receptor–positive cells and pathogenesis of cholestatic liver disease

D Tedesco, M Thapa, CY Chin, Y Ge, M Gong, J Li… - Gastroenterology, 2018 - Elsevier
… of liver fibrosis and inflammation to require hepatic activation … 16 and experimental
hepatectomy regeneration, 17 this … fraction of IL17A + γδ T cells expressed CD161, a marker of …

[HTML][HTML] Inflammation, Immunity, Fibrosis, and Infection: IL-23 mediates murine liver transplantation ischemia-reperfusion injury via IFN-γ/IRF-1 pathway

JR Klune, C Bartels, J Luo, S Yokota, Q Du… - … and Liver Physiology, 2018 - ncbi.nlm.nih.gov
IL-23 acts on CD4 + T cells to cause differentiation into T … and liver damage, whereas IL-23
promotes IFN-γ production … ) on these liver sections for the NKT cell marker CD161. We found …

Decoding the role of immune T cells: A new territory for improvement of metabolic‐associated fatty liver disease

J Liu, M Ding, J Bai, R Luo, R Liu, J Qu, X Li - iMeta, 2023 - Wiley Online Library
… , tissue repair and cell regeneration by expressing the fibroblast … cells or CD161 + and
IL-18Rα + CD8αβ T cells, mainly … and Th17 cells in WAT by activating URI-dependent IL-23/IL-17A …

Type 3 cytokine responses during Non-Alcoholic Fatty Liver Disease (NAFLD)

MN Abdelnabi - 2023 - papyrus.bib.umontreal.ca
liver fibrosis in females, while IL-17A act as profibrogenic cytokine and promotes liver fibrosis
throughT cell (CD3 marker) and NK markers (CD161 in human or NK1.1 in mice)60. NKT …

[HTML][HTML] Intrahepatic th17/treg cells in homeostasis and disease—It's all about the balance

HK Drescher, LM Bartsch, S Weiskirchen… - Frontiers in …, 2020 - frontiersin.org
… are achieved through the differentiation of naïve CD4+ T cells intoIL-21 stimulation
promotes the T H 1 subpopulation … Human T H 17 cells originate from a CD161+ (the human …

The role of the CXCR6/CXCL16 axis in the pathogenesis of fibrotic disease

FT Wang, TQ Wu, Y Lin, YR Jiao, JY Li, Y Ruan… - International …, 2024 - Elsevier
… aggregation and promotes myocardial fibrosis through the … virus (HBV) infection, CD161 +
CD4 + T cells with significant … , compensatory regeneration, steatosis, inflammation, fibrosis, …

[HTML][HTML] Role of γδT cells in liver diseases and its relationship with intestinal microbiota

QH Zhou, FT Wu, LT Pang, TB Zhang… - World Journal of …, 2020 - ncbi.nlm.nih.gov
… of γδT cells, especially Vδ2 T cells, in the liver and peripheral … These cells produce IL-17,
which facilitated fibrosis … and CD161 also increased, revealing cytotoxicity against hepatic