Mapping DNA methylation across development, genotype and schizophrenia in the human frontal cortex
… schizophrenia. We characterized DNAm in prefrontal cortex from 335 non-psychiatric
controls across the lifespan and 191 patients with schizophrenia and identified widespread …
controls across the lifespan and 191 patients with schizophrenia and identified widespread …
Characterizing the dynamic and functional DNA methylation landscape in the developing human cortex
KA Perzel Mandell, AJ Price, R Wilton… - Epigenetics, 2021 - Taylor & Francis
… The dorsolateral prefrontal cortex (DLPFC) is a dynamic … functionally dysregulated in patients
with schizophrenia [Citation8]… ) to capture an unbiased map of the DNAm landscape and to …
with schizophrenia [Citation8]… ) to capture an unbiased map of the DNAm landscape and to …
Cannabinoid receptor CNR1 expression and DNA methylation in human prefrontal cortex, hippocampus and caudate in brain development and schizophrenia
… gene, we acquired the mapped reads covering the CNR1 … differences in methylation in CNR1
by COMT genotype, … in the course of normal human brain development and psychosis. And …
by COMT genotype, … in the course of normal human brain development and psychosis. And …
GAD1 alternative transcripts and DNA methylation in human prefrontal cortex and hippocampus in brain development, schizophrenia
… In this study, the schizophrenia-associated risk genotype in GAD1, rs3749034, … Mapping
DNA methylation across development, genotype and schizophrenia in the human frontal cortex. …
DNA methylation across development, genotype and schizophrenia in the human frontal cortex. …
Variability of DNA methylation within schizophrenia risk loci across subregions of human hippocampus
WB Ruzicka, S Subburaju, FM Benes - Genes, 2017 - mdpi.com
… , a low-level cellular phenotype closely linked to genotype, in … investigated only dorsolateral
prefrontal cortex in adult brain, … mapping that structure onto the complex neural circuitry of the …
prefrontal cortex in adult brain, … mapping that structure onto the complex neural circuitry of the …
Network modules linking expression and methylation in prefrontal cortex of schizophrenia
… In this work, we investigated DNA methylation and gene … can also be influenced by sequence
variants (eg genotype … the module were more likely to be mapped to PGC SZ risk regions (p …
variants (eg genotype … the module were more likely to be mapped to PGC SZ risk regions (p …
DNA methylation in the human frontal cortex reveals a putative mechanism for age-by-disease interactions
… among genetic association-based risk genes for schizophrenia, Alzheimer’s disease (AD), …
in the probe or target site, and probes that map to multiple genetic loci were filtered from the …
in the probe or target site, and probes that map to multiple genetic loci were filtered from the …
Genome-wide mapping of genetic determinants influencing DNA methylation and gene expression in human hippocampus
… -wide SNP genotypes with high-density CpG methylation and gene … We evaluated two sets
of schizophrenia-associated SNPs … its interaction with the prefrontal cortex plays an important …
of schizophrenia-associated SNPs … its interaction with the prefrontal cortex plays an important …
Schizophrenia-associated differential DNA methylation in brain is distributed across the genome and annotated to MAD1L1, a locus at which DNA methylation and …
BC McKinney, LL McClain, CM Hensler, Y Wei… - Translational …, 2022 - nature.com
… Based on the fine-mapping of the GWAS signal at the … = 0.992), according to genotypes from
498 samples of European … This finding is consistent with studies in the prefrontal cortex that …
498 samples of European … This finding is consistent with studies in the prefrontal cortex that …
Regional heterogeneity in gene expression, regulation, and coherence in the frontal cortex and hippocampus across development and schizophrenia
L Collado-Torres, EE Burke, A Peterson, JH Shin… - Neuron, 2019 - cell.com
… We performed RNA-seq in hippocampi and dorsolateral prefrontal cortices (… Mapping
DNA methylation across development, genotype and schizophrenia in the human frontal cortex…
DNA methylation across development, genotype and schizophrenia in the human frontal cortex…