Mapping DNA methylation across development, genotype and schizophrenia in the human frontal cortex

AE Jaffe, Y Gao, A Deep-Soboslay, R Tao… - Nature …, 2016 - nature.com
schizophrenia. We characterized DNAm in prefrontal cortex from 335 non-psychiatric
controls across the lifespan and 191 patients with schizophrenia and identified widespread …

Characterizing the dynamic and functional DNA methylation landscape in the developing human cortex

KA Perzel Mandell, AJ Price, R Wilton… - Epigenetics, 2021 - Taylor & Francis
… The dorsolateral prefrontal cortex (DLPFC) is a dynamic … functionally dysregulated in patients
with schizophrenia [Citation8]… ) to capture an unbiased map of the DNAm landscape and to …

Cannabinoid receptor CNR1 expression and DNA methylation in human prefrontal cortex, hippocampus and caudate in brain development and schizophrenia

R Tao, C Li, AE Jaffe, JH Shin, A Deep-Soboslay… - Translational …, 2020 - nature.com
… gene, we acquired the mapped reads covering the CNR1 … differences in methylation in CNR1
by COMT genotype, … in the course of normal human brain development and psychosis. And …

GAD1 alternative transcripts and DNA methylation in human prefrontal cortex and hippocampus in brain development, schizophrenia

R Tao, KN Davis, C Li, JH Shin, Y Gao, AE Jaffe… - Molecular …, 2018 - nature.com
… In this study, the schizophrenia-associated risk genotype in GAD1, rs3749034, … Mapping
DNA methylation across development, genotype and schizophrenia in the human frontal cortex. …

Variability of DNA methylation within schizophrenia risk loci across subregions of human hippocampus

WB Ruzicka, S Subburaju, FM Benes - Genes, 2017 - mdpi.com
… , a low-level cellular phenotype closely linked to genotype, in … investigated only dorsolateral
prefrontal cortex in adult brain, … mapping that structure onto the complex neural circuitry of the …

Network modules linking expression and methylation in prefrontal cortex of schizophrenia

D Lin, J Chen, K Duan, N Perrone-Bizzozero, J Sui… - Epigenetics, 2021 - Taylor & Francis
… In this work, we investigated DNA methylation and gene … can also be influenced by sequence
variants (eg genotype … the module were more likely to be mapped to PGC SZ risk regions (p …

DNA methylation in the human frontal cortex reveals a putative mechanism for age-by-disease interactions

BC McKinney, CW Lin, T Rahman, H Oh… - Translational …, 2019 - nature.com
… among genetic association-based risk genes for schizophrenia, Alzheimer’s disease (AD), …
in the probe or target site, and probes that map to multiple genetic loci were filtered from the …

Genome-wide mapping of genetic determinants influencing DNA methylation and gene expression in human hippocampus

H Schulz, AK Ruppert, S Herms, C Wolf… - Nature …, 2017 - nature.com
… -wide SNP genotypes with high-density CpG methylation and gene … We evaluated two sets
of schizophrenia-associated SNPs … its interaction with the prefrontal cortex plays an important …

Schizophrenia-associated differential DNA methylation in brain is distributed across the genome and annotated to MAD1L1, a locus at which DNA methylation and …

BC McKinney, LL McClain, CM Hensler, Y Wei… - Translational …, 2022 - nature.com
… Based on the fine-mapping of the GWAS signal at the … = 0.992), according to genotypes from
498 samples of European … This finding is consistent with studies in the prefrontal cortex that …

Regional heterogeneity in gene expression, regulation, and coherence in the frontal cortex and hippocampus across development and schizophrenia

L Collado-Torres, EE Burke, A Peterson, JH Shin… - Neuron, 2019 - cell.com
… We performed RNA-seq in hippocampi and dorsolateral prefrontal cortices (… Mapping
DNA methylation across development, genotype and schizophrenia in the human frontal cortex