Refractory Torsades de Pointes Due to Dofetilide Overdose

J Crosby, H Bhopalwala, A Kharawala… - … High Impact Case …, 2021 - journals.sagepub.com
… Although extremely rare, dofetilide overdose has been described in the literature. However,
… of ongoing dofetilide overdose. We present the case of an intentional dofetilide overdose in …

Antiarrhythmic agents and torsades de pointes

SY Wass, MK Chung - Torsades de Pointes, 2022 - Elsevier
Dofetilide therapy should not be initiated out-of-hospital because of the risk of excessive QT
interval prolongation that can cause torsades de pointes … exceeded either due to overdose or …

[PDF][PDF] Mechanism of Action

MA Ibrahim, CC Kerndt, VS Tivakaran - researchgate.net
… The most likely side effect of overdose is the excessive … remedy for dofetilide overdoses;
treatment of dofetilide overdose is … of dofetilide overdose and torsades de pointes may include …

The Use of Intravenous Lidocaine in the Setting of Chronic Dofetilide Overdose: A Case Report

E Zhu, M Gabriele, MT Nguyen - Journal of Pharmacy …, 2022 - journals.sagepub.com
Torsades de pointes (TdP) was not identified during resuscitation. Defibrillation was …
Amiodarone was held due to a potential interaction with dofetilide and return of spontaneous …

Traditional risk factors for QT interval prolongation and torsades de pointes

KM Sowinski, RJ Kovacs, JE Tisdale - Torsades de Pointes, 2022 - Elsevier
… known to prolong the QT interval; overdose of a potentially proarrhythmic medication; …
dofetilide is eliminated by renal cationic secretion, and concomitant administration of dofetilide

Positive inotropic drugs and drugs used in dysrhythmias

RMA Linger, S Tom, Q Zhong - Side Effects of Drugs Annual, 2022 - Elsevier
Dofetilide overdose-induced refractory torsades de pointes A case of dofetilide overdose-induced
refractory torsades de pointes … taking 20 tablets of 500 μg dofetilide (a total of 10 mg) 4 …

Drug-induced QT interval prolongation and torsades de pointes: Role of the pharmacist in risk assessment, prevention and management

JE Tisdale - Canadian Pharmacists Journal/Revue des …, 2016 - journals.sagepub.com
… virus interacting with amiodarone, disopyramide, dofetilide or pimozide. Other important …
the initiation of therapy, dose increase or overdose. If QT c interval prolongation is observed…

[PDF][PDF] 14 Agents Used in Cardiac Arrhythmias

RD Harvey, AO Grant - Basic & clinical pharmacology, 2018 - academia.edu
… a tendency to cause torsades de pointes arrhythmia. … related to plasma concentration,
dofetilide dosage must be based on the estimated creatinine clearance. Treatment with dofetilide

Positive inotropic drugs and drugs used in dysrhythmias

KA Rambaran, S Alzghari - Side Effects of Drugs Annual, 2019 - Elsevier
… agents as well as reports on overdose. All included material was … polymorphic ventricular
tachycardia/Torsade's de Pointes (TdP)… However, dofetilide was discontinued due to the patient …

Positive Inotropic Drugs and Drugs Used in Dysrhythmias

KA Rambaran, A Lehnert - Side Effects of Drugs Annual, 2018 - Elsevier
… of these agents as well as reports on overdose. All included material was published between
Dofetilide is well known for causing QT prolongation and torsades de pointes (TdP). It was …