… We also saw a concomitant reduction in OEF in vulnerable regions, suggesting that
SANGUINATE resulted in better matching of supply and demand in these high-risk brain regions. …

… cerebral ischemia (DCI) to evaluate tolerability and explore efficacy in improving cerebral
blood flow (CBF) and flow-metabolism balance to vulnerable brain regions. …

… It is a manufactured ∼8 nm nanoparticle with bovine … artery could limit cerebral blood flow
after TBI and catheterization … D), and percent of carboxyhemoglobin (E) in whole blood for pigs …

… PEGylation increases the molecular size and colloid oncotic … significant increase in
carboxyhemoglobin levels. This … Alternatively, Sanguinate’s increase in regional cerebral blood …

… Newton and PEGylated Carboxyhemoglobin Bovine can be … intracranial pressure (ICP),
cerebral blood flow (CBF) probes, and … SANGUINATE TM , a product mentioned in this paper. …

… ) induces redistribution of cerebral blood flow (CBF) and … PP‐007 (formerly known as
SANGUINATE), a carbon … revealed that this increase in PTT was most likely a pegylation process‐…

… the use of Sanguinate, a bovinederived artificial oxygen carrier, … The team reported a
16% rise in regional cerebral blood flow … PEGylated bovine carboxyhemoglobin (SANGUINATE™): …

… substitutes that are currently undergoing testing, known as PEGylated … They were made
using outdated human or bovine blood, … Sanguinate has been granted orphan drug status for …

… curve, an increased viscosity and a PEGylated coat surrounding a small Hb-based …
subarachnoid hemorrhage treated with Sanguinate, an improvement in regional cerebral blood flow …

… repair of ruptured subarachnoid hemorrhage, there were no … , had an increase in blood
flow during xenon administration. In … in the context of vulnerable cerebral perfusion in place of …