… Our results demonstrate that SGK1.1 activation leads to reduced seizure severity and lower
… by reduced number, shorter duration, and early termination of kainate-induced seizures in …

… Using a kainic acid-induced model of temporal lobe epilepsy … factor, shortening seizure
severity and duration independently … mechanisms which lead to abnormally prolonged seizures (…

… robust protection against seizures associated to lower mortality levels, … to KA-seizures,
potently decreasing seizure severity. … to hypothesize that reduced excitability due to increased M-…

… comparable seizure severity. (… led us to hypothesize that other features found in patients
with TLE, such as reactive gliosis, would be also reduced in our animal model after the epileptic …

… , leading to reduced excitability and protection against seizures. We … levels, significantly
reducing seizure severity. We now … Reduces Kainic Acid-Induced Seizure Severity and Leads to …

… , leading to reduced excitability and protection against seizures. … -dependent outward current
that leads to the stabilization of … .1 potently reduces seizure severity and duration in a kainic …

… neuronal excitability via up-regulation of M-current, linked to Kv7.2/3 potassium channels. …
to kainic acid-induced seizures, which supports a role for SGK1.1 protein in reducing …

… our electrophysiological findings is the reduced expression of Kv7.2/7.3 in epileptic tissue,
we … .1 reduces kainic acid-induced seizure severity and leads to rapid termination of seizures …

… channels effectively reduces seizures in humans and in multiple animal models of epilepsy
(… M-current display diminished sensitivity to kainic acid-induced seizures (Miranda et al. 2013)…

… Behavioral changes were evaluated at the end of the drug … observed in seizures, and reducing
epileptic neurogenesis … CNS) could affect seizure severity and lead to some comorbidities …