TIFA promotes colorectal cancer cell proliferation in an RSK‐and PRAS40dependent manner

W Shen, W Du, Y Li, Y Huang, X Jiang, C Yang… - Cancer …, 2022 - Wiley Online Library
… In conclusion, we discovered that TIFA promotes cell proliferation in CRC cell lines in vitro …
TIFA mediates RSK and PRAS40 activation to facilitate protein synthesis, which relied on TIFA

TIFA Promotes CRC Cell Proliferation via RSK-and PRAS40-Dependent Manner

W Shen, W Du, Y Li, Y Huang, X Jiang, C Yang, J Tang… - 2021 - researchsquare.com
… level of TIFA in patients with colorectal cancer in GEPIA and … that TIFA promotes cell
proliferation in CRC cell line in vitro … We revealed that TIFA mediates RSK and PRAS40 activation …

TBX21 attenuates colorectal cancer progression via an ARHGAP29/RSK/GSK3β dependent manner

X Jiang, W Du, C Yang, S Wang, Y Li, X Shen, X Yang… - Cellular Oncology, 2023 - Springer
… CRC tumor progression via inhibiting cell proliferation and promoting cell apoptosis in vitro,
… ARHGAP29 and promoting ARHGAP29 expression, inhibits RSK and PRAS40 activation in …

[HTML][HTML] Helicobacter pylori regulates TIFA turnover in gastric epithelial cells.

O Sokolova, G Maubach, M Naumann - European Journal of Cell Biology, 2023 - Elsevier
TIFA has been suggested to promote oligomerization and activity of the E3 … -dependent
TIFA activation in H. pylori-infected gastric epithelial cells is followed in time by a decline in TIFA

Dual-Specificity Phosphatase 4 Promotes Malignant Features in Colorectal Cancer Through Cyclic-AMP Response Element Binding Protein/Protein Kinase CAMP …

W Pei, W Yin, T Yu, X Zhang, Q Zhang, X Yang… - Digestive Diseases and …, 2024 - Springer
… In our study, we found that DUSP4 functions as an oncogene that is highly expressed in
colorectal cancer, promotes cell proliferation, and inhibits apoptosis in colorectal cancer in vitro …

Identification of potential biomarkers and infiltrating immune cells from scalp psoriasis

S Liu, Z Zhuang, F Liu, X Yuan, Z Zhang, X Liang, X Li… - Gene, 2024 - Elsevier
… could affect keratinocytes proliferation by regulating TIFA, and RPL9 and TIFA may play a …
HaCat cells proliferation and the TNF-α secretion by regulating TIFA. In addition, the RPL9/…

At a crossroads: how to translate the roles of PI3K in oncogenic and metabolic signalling into improvements in cancer therapy

N Vasan, LC Cantley - Nature Reviews Clinical Oncology, 2022 - nature.com
… functions, including TSC2 and PRAS40 (protein synthesis), … Subsequently, using knock-in
mutant colorectal cancer cell … The randomized phase II TIFA trial 103 is testing whether a …