… of this study is to test if a 6-month treatment of a combination of l-citrulline and metformin is
more effective than placebo in preventing loss of motor function and muscle degeneration in …

… Duchenne muscular dystrophy, treatment with a combination of l-citrulline and metformin …
qMRI results in a randomized placebo-controlled clinical trial. Because corticosteroids slow …

… Before and after treatment, we measured in serum and urine … Metformin treatment
resulted in concentration decrease of … is a milder form of Duchenne muscular dystrophy (DMD). …

… We investigated if our chronic treatment with metformin was able to impact on the level of …
NO precursors, l-citrulline and l-arginine, in TA muscles via HPLC. In parallel, we measured the …

… for the treatment of DMD by the EMA, and a randomized, … , metformin/l-citrulline experimentation
is being moved on to a larger, randomized, double-blind, placebo-controlled trial with a …

… of the Treatment with L-citrulline and metformin in Duchenne muscular dystrophy (DMD02)
study [52]… This multicenter, randomized, double-blind and placebo-controlled trial investigates …

… Hopefully, a similar study will follow soon with an increased cohort size and perhaps a
longer treatment period. The same group also investigated Metformin with l-Citrulline in a small …

… to 10 years treated with a combination of 2.5 g L-citrulline and 0.25 g metformin three times
a … , a randomized double-blinded placebo-controlled trial was conducted in another genetic …

… DMD therapy can be divided into approaches targeting dystrophin … a randomized double-blind
clinical trial on 47 ambulant DMD patients revealed that overall l-citrulline plus metformin …

… [26] (as a single and combined treatment with L-citrulline) … A recent single centre open label
study was conducted to … The phase II, double-blind, placebo-controlled study enrolled 51 …