[HTML][HTML] Identification of drug-specific public TCR driving severe cutaneous adverse reactions
RY Pan, MT Chu, CW Wang, YS Lee… - Nature …, 2019 - nature.com
… whether drug-specific TCR clonotypes mediate the hypersensitivity reactions. In this study, …
Here, we report the discovery of preferential TCR clonotypes from the blister cells of the skin …
Here, we report the discovery of preferential TCR clonotypes from the blister cells of the skin …
[HTML][HTML] Evaluating T-cell cross-reactivity between tumors and immune-related adverse events with TCR sequencing: pitfalls in interpretations of functional relevance
… overlap of TCR clonotypes between tumor and irAE tissues8–10 and that expansion of
peripheral blood T-cell clones prior to irAE onset positively correlates with irAE severity during …
peripheral blood T-cell clones prior to irAE onset positively correlates with irAE severity during …
Severe cutaneous adverse reactions
SI Hung, M Mockenhaupt, KG Blumenthal… - Nature Reviews …, 2024 - nature.com
… (SCARs) are a group of adverse reactions resulting from drug-induced T cell-mediated
hypersensitivity characterized by severe skin eruptions and varying degrees of systemic …
hypersensitivity characterized by severe skin eruptions and varying degrees of systemic …
Massive clonal expansion of polycytotoxic skin and blood CD8+ T cells in patients with toxic epidermal necrolysis
AP Villani, A Rozieres, B Bensaid, KK Eriksson… - Science …, 2021 - science.org
… a life-threatening cutaneous adverse drug reaction. To better understand why skin symptoms
are so severe, we conducted a prospective immunophenotyping study on skin and blood. …
are so severe, we conducted a prospective immunophenotyping study on skin and blood. …
Monitoring malignant T‐cell clones by direct TCR expression assay in patients with leukemic cutaneous T‐cell lymphoma during extracorporeal photopheresis
… Further studies correlating clinical response with TCR clonotypes and usages by malignant
T-… We also plan to apply DTEA to skin samples of MF/SS patients and assess its value in the …
T-… We also plan to apply DTEA to skin samples of MF/SS patients and assess its value in the …
Comprehensive assessment of T cell receptor β repertoire in Stevens–Johnson syndrome/toxic epidermal necrolysis patients using high-throughput sequencing
H Xiong, L Wang, M Jiang, S Chen, F Yang, H Zhu… - Molecular …, 2019 - Elsevier
… severe cutaneous adverse drug reactions characterized by widespread epidermal necrosis.
Recent studies have indicated that SJS/TEN is a specific immune reaction … TCR clonotypes …
Recent studies have indicated that SJS/TEN is a specific immune reaction … TCR clonotypes …
Clonotypic diversity of the T-cell receptor corroborates the immature precursor origin of cutaneous T-cell lymphoma
A Hamrouni, H Fogh, Z Zak, N Ødum… - Clinical Cancer Research, 2019 - AACR
… All TCR clonotypes detected were considered in the analysis, irrespective of their functionality
(productive or unproductive). All samples were sequenced in duplicates yielding similar …
(productive or unproductive). All samples were sequenced in duplicates yielding similar …
Skin colonization by circulating neoplastic clones in cutaneous T-cell lymphoma
A Iyer, D Hennessey, S O'Keefe… - Blood, The Journal …, 2019 - ashpublications.org
… By comparing TCR clonotypes in the skin and blood in patients with MF, we reveal a
complex pattern of recirculation of tumor subclones. We propose that the substantial clonotypic …
complex pattern of recirculation of tumor subclones. We propose that the substantial clonotypic …
[HTML][HTML] Genetics of severe cutaneous adverse reactions
SC Yang, CB Chen, MY Lin, ZY Zhang, XY Jia… - Frontiers in …, 2021 - frontiersin.org
… Cutaneous reactions are most common manifestations seen in hypersensitivity reactions of
drugs, named cutaneous adverse drug reactions… into severe cutaneous adverse reactions (…
drugs, named cutaneous adverse drug reactions… into severe cutaneous adverse reactions (…
[HTML][HTML] New strategies to predict and prevent serious immunologically mediated adverse drug reactions
EJ Phillips - Transactions of the American Clinical and …, 2018 - ncbi.nlm.nih.gov
… ), blister fluid, and skin from patients with acute serious cutaneous ADRs such as SJS/TEN …
during the acute disease, particularly when these are associated with public TCR clonotypes, …
during the acute disease, particularly when these are associated with public TCR clonotypes, …
相关搜索
- severe cutaneous adverse reactions cytotoxic proteins
- severe cutaneous adverse reactions diagnostic methods
- severe cutaneous adverse drug reactions
- immunological pathogenesis cutaneous adverse drug reactions
- adverse events tcr sequencing
- immune mediated adverse drug reactions
- skin colonization cutaneous t cell lymphoma
- severe cutaneous adverse reactions clinical presentation
- hla allele adverse drug reactions
- severe cutaneous adverse reactions therapeutic targets
- susceptible genes cutaneous adverse drug reactions
- chinese hans cutaneous adverse drug reactions
- genetic prediction adverse drug reactions
- pathogenesis of adverse drug reactions
- idiosyncratic adverse drug reactions