[HTML][HTML] Biased, Bitopic, Opioid–Adrenergic Tethered Compounds May Improve Specificity, Lower Dosage and Enhance Agonist or Antagonist Function with Reduced …

R Root-Bernstein - Pharmaceuticals, 2022 - mdpi.com
… that adrenergic-opioid enhancement can be mediated by … is involved, the synergy that
results is mediated by these … human α2C-adrenergic receptor ligand that increased receptor

Alpha2C-adrenoceptor Del322-325 polymorphism and risk of psychiatric disorders: significant association with opiate abuse and dependence

G Rivero, I Martín-Guerrero, E de Prado… - The World Journal of …, 2016 - Taylor & Francis
… Finally, the analgesic synergy between the noradrenergic and opioid system has been
extensively … Analgesic synergy, at least at the spinal level, seems to be mediated by α 2C -AR (…

[HTML][HTML] The influence of dexmedetomidine on remifentanil‑induced hyperalgesia and the sex differences

H Qiu, Z Sun, F Shadhiya… - Experimental and …, 2018 - spandidos-publications.com
… on α2 adrenergic receptor agonists have been shown to produce significant synergy with …
a common complication of general anesthesia and spinal anesthesia. Recently, the effect of …

In vitro and in silico characterization of G-protein coupled receptor (GPCR) targets of phlorofucofuroeckol-A and dieckol

P Paudel, SH Seong, SE Park, JH Ryu, HA Jung… - Marine Drugs, 2021 - mdpi.com
α2C adrenergic receptor (α 2C AR) and an antagonist effect at the adenosine 2A receptor (A
2A R), δ-opioid receptor (… At present, GPCRs mediate the effect of approximately one-third of …

Zerumbone-induced analgesia modulated via potassium channels and opioid receptors in chronic constriction injury-induced neuropathic pain

B Gopalsamy, JSM Chia, AAO Farouk, MR Sulaiman… - Molecules, 2020 - mdpi.com
… maintenance of pain symptoms. Even though this chronic pain state is mediated by both …
The changes can occur in the peripheral nerves, dorsal root ganglion, spinal cord, along the …

management of pain associated with laminitis in the horse-evidence for therapies.

KL Ellis, MR King, KR Mama - 2020 - cabidigitallibrary.org
α2C-Adrenergic receptors mediate spinal analgesia and adrenergic-opioid synergy. J …
evoked by α2 agonists and is necessary for spinal adrenergic-opioid synergy. J Neurosci …

[PDF][PDF] Concomitant use of medetomidine and vatinoxan in laboratory and client-owned dogs–Effects on drug absorption and disposition

I Kallio-Kujala - 2021 - helda.helsinki.fi
… and any remaining spinal fluid or blood was absorbed with a gauze from the tissue samples.
Tissue samples were obtained from the lumbar and cervical spinal intumescences and from …

… of clonidine and magnesium sulfate premedication on perioperative hormonal stress responses, hemodynamic stability and postoperative analgesia in patients with …

HS Mohamed Ali, GS Gad… - … Journal of Anaesthesia, 2022 - Taylor & Francis
… have better postoperative pain relief with lower consumption of rescue analgesics than in …
of post-operative pain represents a unique challenge and multimodal analgesia is usually …

[PDF][PDF] Supplemental Table Legend

JRH VI, MF Bear, P Golshani, E Klann, SA Lipton… - researchgate.net
… D2-like dopamine receptors mediate the response to amphetamine in a mouse model of …
The α2C-adrenergic receptor mediates hyperactivity of coloboma mice, a model of attention …

アドレナリンα2A 受容体サブタイプに対するα2 作動薬の作用に関する研究

小林武志 - 2017 - eprints.lib.hokudai.ac.jp
… The α2a adrenergic receptor subtype mediates spinal analgesia evoked by α2 agonists
and is necessary for spinal adrenergicopioid synergy. J neurosci 17: 7157-7165. …