[HTML][HTML] Mitochondrial Complex I and β-Amyloid Peptide Interplay in Alzheimer's Disease: A Critical Review of New and Old Little Regarded Findings
… decrease (30–40%) in the activity of complex IV (see [35,36])… models, confirmed mitochondrial
fragmentation, associated … , see [25]), likely due to the incorrect assembly of complex I. An …
fragmentation, associated … , see [25]), likely due to the incorrect assembly of complex I. An …
[HTML][HTML] Amyloid-β impairs mitochondrial dynamics and autophagy in Alzheimer's disease experimental models
M de la Cueva, D Antequera, L Ordoñez-Gutierrez… - Scientific Reports, 2022 - nature.com
… explained as the mitochondrial biogenesis is reduced but also … fragmentation and impaired
mitochondrial transport in Aβ-… biogenesis was also previously demonstrated 34,35 . Other …
mitochondrial transport in Aβ-… biogenesis was also previously demonstrated 34,35 . Other …
Baicalin attenuates amyloid β oligomers induced memory deficits and mitochondria fragmentation through regulation of PDE-PKA-Drp1 signalling
HY Yu, Y Zhu, XL Zhang, L Wang, YM Zhou… - …, 2022 - Springer
… complex iron sulphur subunit B (SDHB) and cytochrome c oxidase components I (COXI) and
mitochondrial fragmentation in the hippocampus. Further, we found that baicalin decreased …
mitochondrial fragmentation in the hippocampus. Further, we found that baicalin decreased …
Synaptic mitochondria: an early target of amyloid-β and tau in Alzheimer's disease
AK Torres, C Jara, HS Park-Kang… - Journal of …, 2021 - content.iospress.com
… Moreover, Aβ 42 promotes mitochondrial dysfunction [33–35]… This complex IV activity
decrease is in line with evidence … tau increases mitochondrial fragmentation and mitochondrial …
decrease is in line with evidence … tau increases mitochondrial fragmentation and mitochondrial …
PINK1 regulates mitochondrial fission/fusion and neuroinflammation in β-amyloid-induced Alzheimer's disease models
X Wang, Y Xue, Y Yao, Y Li, X Ji, T Chi, P Liu… - Neurochemistry …, 2022 - Elsevier
… complex I, complex III, complex V activity, and ATP levels were … reduced in Aβ 25-35 -SD
rats, and a greater decrease was … Aβ 25-35 is an important toxic Aβ fragment and the Aβ 25-35 …
rats, and a greater decrease was … Aβ 25-35 is an important toxic Aβ fragment and the Aβ 25-35 …
Sigma-1 receptor agonists induce oxidative stress in mitochondria and enhance complex I activity in physiological condition but protect against pathological oxidative …
… Aβ 25–35 -induced decrease in complex IV activity and … 41, AN2-73, AN3-71) selectively
increased complex I activity. The σ 1 R … preparation, we only have ER fragments that may not be …
increased complex I activity. The σ 1 R … preparation, we only have ER fragments that may not be …
Amyloid targeting “artificial chaperone” impairs oligomer mediated neuronal damage and mitochondrial dysfunction associated with Alzheimer's disease
… also increases and attains a maximum value at 24 h and … binding at the Aβ16–21 fragment
irrespective of its conformation. … It targets Aβ40 through selective binding at the amyloidogenic …
irrespective of its conformation. … It targets Aβ40 through selective binding at the amyloidogenic …
The mitochondria-targeted small molecule SS31 delays progression of behavioral deficits by attenuating β-amyloid plaque formation and mitochondrial/synaptic …
YL Jia, W Wang, N Han, HL Sun, FM Dong… - Biochemical and …, 2023 - Elsevier
… that SS31 lowers ROS and Aβ levels, protecting mitochondrial … excessive fragmentation of
mitochondria make it difficult for … antioxidants that selectively locate to the mitochondrial inner …
mitochondria make it difficult for … antioxidants that selectively locate to the mitochondrial inner …
Sildenafil protects neuronal cells from mitochondrial toxicity induced by β-amyloid peptide via ATP-sensitive K+ channels
Y Son, K Kim, H Cho - Biochemical and biophysical research …, 2018 - Elsevier
… cells with Aβ 25∼35 results in increased mitochondrial Ca 2+ … mitochondrial Ca 2+ overload
is accompanied by decrease in … The shortened fragment of Aβ 25∼35 contains the residues …
is accompanied by decrease in … The shortened fragment of Aβ 25∼35 contains the residues …
Mitochondria in excitatory and inhibitory synapses have similar susceptibility to amyloid-β peptides modeling Alzheimer's disease
… The Aβ 1–42 peptide fragment (Bachem) was dissolved in … of synaptotoxicity [35], we
measured the activity of caspase 3 … mitochondrial dysfunction, namely lower metabolic reducing …
measured the activity of caspase 3 … mitochondrial dysfunction, namely lower metabolic reducing …