… this devastating disease of brain and mind. … of cathepsin D (CatD), a lysosomal aspartyl
protease discovered more than 40 years ago [21], results in dramatic, ∼3 to ∼4-fold increases in …

… cathepsins B and D [12, 13, 15]. Transgenic (Tg) mice overexpressing Aβ also exhibit an
up-regulation of EL markers including cathepsin D (CatD) in selected brain … an increased level …

… and neuroinflammation, however we observed an increased level of Aβ 1–42 in the CSF. …
the brain lysates revealed that cathepsin-D deficiency did not alter the expression levels of …

… accumulation and aggregation of β-amyloid (Aβ) … brain cortical tissues and blood from
separate cohorts of aged non-dementia and dementia patients, the current study reports increased …

… , we quantified rates of Aβ degradation in vitro in soluble brain extracts … levels of Aβ averaged
over the entire volume of the cerebrum. The ~ 4-fold increase in whole-brain Aβ42 levels …

… Increased immunoreactivities of an important lysosomal … disorder characterized by deposition
of β-amyloid (Aβ) as senile … in decreased protein levels of Cat D in the brain, we performed …

… an increase/decrease in Aβ peptides levels whereas … Potential correlation between
amyloid deposition in the brain … ELISAs (INNOTEST® β-amyloid (1–42) and β-amyloid (1–40), …

… was reported in the brain of cathepsin D knock-down zebrafish … of lipofuscin in cathepsin D
deficient neurons is a chronic … the brain of AD patients, cathepsin D expression is increased …

… cognitive decline as well as with brain atrophy provide a potential … links between tau pathology
and brain atrophy in AD. For … In the context of our study, the increased catD levels found in …

… Higher levels of cathepsin D expression in the brain, including the cortex, hippocampus, …
Increased cathepsin D levels were also observed in neurofibrillary tangles of parietal cortex …