Association of education with Aβ burden in preclinical familial and sporadic Alzheimer disease

…, RJ Bateman, J Poirier, JCS Breitner, S Villeneuve… - Neurology, 2020 - AAN Enterprises
… the ε4 risk allele at APOE influence β-amyloid (Aβ) pathology … studies showing an association
between physical activity … found that education was protective against the onset of cognitive …

A disulfide-stabilized Aβ that forms dimers but does not form fibrils

S Zhang, S Yoo, DT Snyder, BB Katz, A Henrickson… - Biochemistry, 2022 - ACS Publications
… the β-amyloid peptide Aβ. Although Aβ fibrils are the most commonly found Aβ species in
Alzheimers … The reduced Aβ C18C33 peptide behaves more like Aβ (M1–42) , showing distinct …

Effective anti-Alzheimer Aβ therapy involves depletion of specific Aβ oligomer subtypes

…, NR Relkin, M Ehrlich, CG Glabe, S Gandy… - Neuroimmunology & …, 2016 - AAN Enterprises
… of the neurotoxic β-amyloid (Aβ) peptide. Removing existing soluble … In the present study,
IG protection was not associated with … View our submission guidelines for Letters to the Editor …

Preparation, Conjugation, and Stabilization of Amyloid-β Peptides

S Zhang - 2021 - search.proquest.com
… Vina to show the interaction of the cyclic peptide inhibitor … step-by-step protocol showing the
inhibitor design process. … synthesis and antiproliferative activity towards prostate cancer cells…

Microglial cathepsin E plays a role in neuroinflammation and amyloid β production in Alzheimer's disease

Z Xie, J Meng, W Kong, Z Wu, F Lan, Narengaowa… - Aging …, 2022 - Wiley Online Library
… and β-amyloid (Aβ) production are critical factors in the pathogenesis of Alzheimer's disease
… The failure of therapies based on administration of peptides via intravenous or oral routes is …

Age-accelerated cognitive decline in asymptomatic adults with CSF β-amyloid

…, E Jonaitis, K Blennow, BB Bendlin, S Asthana… - Neurology, 2018 - AAN Enterprises
Alzheimer disease (AD) focus on older adults, recent studies report that middle-aged adults
with CSF biomarkers of both β-amyloid (Aβ) and tau exhibit … positivity would exhibit greater …

A phase 3 trial of IV immunoglobulin for Alzheimer disease

…, PS Aisen, Alzheimer's Disease Cooperative Study… - Neurology, 2017 - AAN Enterprises
… low-dose human IVIg for 18 months but did not show beneficial … The abnormal brain
accumulation of β-amyloid (Aβ) is a ubiquitous … specific for amyloid peptide epitopes or …

Poor sleep is associated with CSF biomarkers of amyloid pathology in cognitively normal adults

…, K Blennow, OC Okonkwo, MA Sager, S Asthana… - Neurology, 2017 - AAN Enterprises
… of amyloid metabolism and plaques (β-amyloid 42 [Aβ42]), tau … an Aβ triplex assay (MSD
Humanpeptide Ultra-Sensitive Kit, … Furthermore, we show that the relationship is detectable …

Evaluation of a novel immunoassay to detect p-tau Thr217 in the CSF to distinguish Alzheimer disease from other dementias

…, H Kvartsberg, E Kontsekova, L Fialova, S Katina… - Neurology, 2020 - AAN Enterprises
… p-tau T181, total tau and β-amyloid 40, but not β-amyloid 42. … We prepared the pT217
calibrator as a synthetic peptide … Our results show that the assay discriminates between AD and …

Plasma tau correlates with basal forebrain atrophy rates in people at risk for Alzheimer disease

, … Group and the Alzheimer Precision Medicine Initiative - Neurology, 2020 - AAN Enterprises
… to tauopathy and not to β-amyloid (Aβ) pathophysiology. … and low CSF Aβ 1-42 peptide
levels. Interestingly, both cross-… Our results show that an elevated baseline concentration of …