… to the pancreatic ECM plays crucial roles in β-cell survival and … of β-cells is linked to their
proliferation and survival, as well as … β1-integrin subunit is the most highly expressed β-integrin …

… beta-cell function and expansion. This study further demonstrates that β1 integrin in adult
pancreatic beta-cells is essential for maintaining normal beta-cell mass and insulin secretion. …

… , β-cell-specific β1 integrin inactivation model, the β1 integrin … reduced β-cell mass as a result
of a decrease in proliferation … the β1 integrin plays a key role in β-cell mass expansion and …

… , β1 integrin plays a crucial role in establishing β-cell mass by regulating expansion of …
Although integrin signaling can lead to β-cell proliferation, our knowledge is limited regarding …

… This mechanism might be important for islet function and … in which activation of integrin β1,
at the β cell vascular face, drives … Block of integrin β1, inhibition of focal adhesion kinase, and …

… mass due to a lack of cell proliferation, and impaired insulin secretion in adult life (12).
Furthermore, in adult islets, β1-integrin has proven to be important for beta-cell survival, insulin …

… of beta-cell β1 integrin expression is critical during the … and proliferation were observed in
fetal MIPβ1KO mice, downstream β1 integrin signaling pathways involved in cell proliferation …

… , αv, β1, β3, and β5 integrin subunits in mature human islets, while β1 is known to play a
pivotal role in regulating β-cell mass … signals that influence β-cell proliferation and function. The …

… pancreas, interaction between the ECM and islet cells via adhesion-mediated integrin
signaling has been shown to play a crucial … subunit as well as both the β1 and β5 but not the β3 …

… receptor can interact with α 4 β 1 , α 5 β 1 and α 9 β 1 integrins and with Ig superfamily cell…
β 1 and γ 1 chains) and -laminin-511 have been found to be essential for beta cell proliferation …