Adenosine receptor-mediated cardioprotection—current limitations and future directions

RD Lasley - Frontiers in Pharmacology, 2018 - frontiersin.org
… The purpose of this Perspective article is to discuss these deficiencies to highlight future
directions of research in the field of adenosine receptor-mediated protection of ischemic …

The use of β2-adrenoreceptor agonists in viral bronchiolitis: scientific rationale beyond evidence-based guidelines

G Nino, CE Rodríguez-Martínez… - ERJ Open …, 2020 - Eur Respiratory Soc
current scientific evidence that may help to identify possible phenotypes or subgroups of
responders to β 2 -AR agonist … be the starting point for future targeted randomised clinical trials …

Activation of β2 adrenergic receptor signaling modulates inflammation: a target limiting the progression of kidney diseases

D Dorotea, H Ha - Archives of Pharmacal Research, 2021 - Springer
β 2 -agonists are notably present. Increasing amounts of evidence have unveiled the alternative
mechanisms of the β 2 -AR agonistsFuture clinical trials focusing on the renal outcome, …

The future of bronchodilation: looking for new classes of bronchodilators

M Cazzola, P Rogliani… - European Respiratory …, 2019 - Eur Respiratory Soc
… Functional CaSRs are present in adult human ASM and regulate basal and agonist-induced
[Ca 2+ ] i , as well as contractility [74]. CaSRs are upregulated and constitutively activated in …

β2adrenoceptor agonists and antagonists and risk of Parkinson's disease

N Gronich, DR Abernethy, E Auriel, I Lavi… - Movement …, 2018 - Wiley Online Library
trends over time in the use of newly introduced β2-agonists … for covariates that were present
only before cohort entry to … β-antagonists and β2-agonists only if they were present at least 2, …

G-protein-coupled receptor kinase 2 (GRK2) inhibitors: current trends and future perspectives

M Guccione, R Ettari, S Taliani… - Journal of medicinal …, 2016 - ACS Publications
… Compound 2a was used in a recent study to evaluate its effects on agonist-induced μ-opioid
receptor (MOPr) desensitization in locus coeruleus neurons. (100) In HEK 293 cells, 2a …

Investigational beta-2 adrenergic agonists for the treatment of chronic obstructive pulmonary disease

M Malerba, A Radaeli, P Montuschi… - Expert Opinion on …, 2017 - Taylor & Francis
… C-1 hydroxy group that is present in most β2-adrenoceptor agonists, but has incorporated
a … or twice-daily doses will address unresolved questions in future and current clinical trials. …

Role of β2-adrenergic receptors in chronic obstructive pulmonary disease

A Yang, G Yu, Y Wu, H Wang - Life Sciences, 2021 - Elsevier
… the symptoms and prognosis of COPD patients in the future. … In this review, we discuss and
update recent research on β2-… Also, the precision diagnosis will provide us another direction

Beta2-adrenoreceptor agonists and long-term risk of Parkinson's disease

JA Tuominen, K Bjørnevik, J Romanowska… - Parkinsonism & related …, 2023 - Elsevier
… In this prospective study of the Norwegian population, we estimated the incidence of …
Adjusting for level of education in the present study did not notably influence the risk estimates …

Next generation beta adrenoreceptor agonists for the treatment of asthma

E Crisafulli, A Frizzelli, A Fantin, A Manco… - Expert Opinion on …, 2017 - Taylor & Francis
Introduction: A fixed-dose inhalation of a long-acting β-agonist (LABA) and inhaled
corticosteroids (ICS) is commonly recommended for moderate to severe asthmatic patients not …