Characterizing the mode of action of super long-acting beta2-adrenergic receptor agonists: A more effective therapeutic for Parkinson's disease.
NB Arbabzada - 2016 - era.library.ualberta.ca
… The long-acting β2-adrenergic receptor (β2-AR) agonist … Recently, super long-acting β2-AR
agonists vilanterol and … of these super long-acting agonists on the inflammatory response of …
agonists vilanterol and … of these super long-acting agonists on the inflammatory response of …
β3-Adrenoceptor agonists for overactive bladder syndrome: Role of translational pharmacology in a repositioning clinical drug development project
MC Michel, C Korstanje - Pharmacology & Therapeutics, 2016 - Elsevier
… β 3 -Adrenoceptor agonists were originally considered as a promising drug class for the …
Based on the example of the β 3 -adrenoceptor agonist mirabegron, but also taking into …
Based on the example of the β 3 -adrenoceptor agonist mirabegron, but also taking into …
Structural insights into binding specificity, efficacy and bias of a β2AR partial agonist
M Masureel, Y Zou, LP Picard… - Nature chemical …, 2018 - nature.com
… agonist for the β 2 adrenergic receptor (β 2 AR) and the first long-acting β 2 AR agonist to …
, we obtained the crystal structure of salmeterol-bound β 2 AR in complex with an active-state-…
, we obtained the crystal structure of salmeterol-bound β 2 AR in complex with an active-state-…
Muscarinic antagonists in early stage clinical development for the treatment of asthma
TE Albertson, JA Chenoweth, JY Adams… - Expert Opinion on …, 2017 - Taylor & Francis
… asthma patients will likely become the future standard. … or paired with a long-acting beta 2
agonist (LABA) for maintenance … This paper reviews the current literature and ongoing studies …
agonist (LABA) for maintenance … This paper reviews the current literature and ongoing studies …
[HTML][HTML] Current and future therapeutic perspective in chronic heart failure
A Mascolo, G Di Mauro, D Cappetta… - Pharmacological …, 2022 - Elsevier
… (HFmrEF) since no substantial prospective randomized clinical trial has been performed
exclusively in such population. According to the recent 2021 European Society of Cardiology (…
exclusively in such population. According to the recent 2021 European Society of Cardiology (…
Adrenergic downregulation in critical care: molecular mechanisms and therapeutic evidence
A Belletti, G Landoni, VV Lomivorotov, A Oriani… - Journal of cardiothoracic …, 2020 - Elsevier
… the current evidence concerning the role of adrenergic receptor desensitization and
downregulation in the acute care setting and discuss potential implications for therapy and future …
downregulation in the acute care setting and discuss potential implications for therapy and future …
Beta-blockers: current state of knowledge and perspectives
M Ogrodowczyk, K Dettlaff… - Mini reviews in medicinal …, 2016 - ingentaconnect.com
… It also has a direct vasodilating effect on the blood vessels, which can be related to the
agonistic effect on β 2adrenoceptors located in the vessels. The strongest betablocking effect is …
agonistic effect on β 2adrenoceptors located in the vessels. The strongest betablocking effect is …
How Carvedilol activates β2-adrenoceptors
T Benkel, M Zimmermann, J Zeiner, S Bravo… - Nature …, 2022 - nature.com
… present study, and the uncovered mechanism that carvedilol exerts its positive signalling
through β 2 … Notwithstanding these caveats, our new knowledge adds value to the future use of …
through β 2 … Notwithstanding these caveats, our new knowledge adds value to the future use of …
The β2-adrenergic receptor-ROS signaling axis: An overlooked component of β2AR function?
KM Rambacher, NH Moniri - Biochemical pharmacology, 2020 - Elsevier
… The β2-adrenergic receptor (β2AR), a prototype of the G protein-coupled receptor (GPCR) …
rapid bronchodilation and is therefore the current gold standard for therapeutic treatment of …
rapid bronchodilation and is therefore the current gold standard for therapeutic treatment of …
The Principles of Ligand Specificity on beta-2-adrenergic receptor
… fingerprint of the β 2 -adrenergic receptor (β 2 AR). β-adrenoceptors belong to rhodopsin-like …
& Matera, MG beta(2) -adrenoceptor agonists: current and future direction. British journal of …
& Matera, MG beta(2) -adrenoceptor agonists: current and future direction. British journal of …