Characterizing the mode of action of super long-acting beta2-adrenergic receptor agonists: A more effective therapeutic for Parkinson's disease.

NB Arbabzada - 2016 - era.library.ualberta.ca
… The long-acting β2-adrenergic receptor (β2-AR) agonist … Recently, super long-acting β2-AR
agonists vilanterol and … of these super long-acting agonists on the inflammatory response of …

β3-Adrenoceptor agonists for overactive bladder syndrome: Role of translational pharmacology in a repositioning clinical drug development project

MC Michel, C Korstanje - Pharmacology & Therapeutics, 2016 - Elsevier
… β 3 -Adrenoceptor agonists were originally considered as a promising drug class for the …
Based on the example of the β 3 -adrenoceptor agonist mirabegron, but also taking into …

Structural insights into binding specificity, efficacy and bias of a β2AR partial agonist

M Masureel, Y Zou, LP Picard… - Nature chemical …, 2018 - nature.com
agonist for the β 2 adrenergic receptor (β 2 AR) and the first long-acting β 2 AR agonist to …
, we obtained the crystal structure of salmeterol-bound β 2 AR in complex with an active-state-…

Muscarinic antagonists in early stage clinical development for the treatment of asthma

TE Albertson, JA Chenoweth, JY Adams… - Expert Opinion on …, 2017 - Taylor & Francis
… asthma patients will likely become the future standard. … or paired with a long-acting beta 2
agonist (LABA) for maintenance … This paper reviews the current literature and ongoing studies …

[HTML][HTML] Current and future therapeutic perspective in chronic heart failure

A Mascolo, G Di Mauro, D Cappetta… - Pharmacological …, 2022 - Elsevier
… (HFmrEF) since no substantial prospective randomized clinical trial has been performed
exclusively in such population. According to the recent 2021 European Society of Cardiology (…

Adrenergic downregulation in critical care: molecular mechanisms and therapeutic evidence

A Belletti, G Landoni, VV Lomivorotov, A Oriani… - Journal of cardiothoracic …, 2020 - Elsevier
… the current evidence concerning the role of adrenergic receptor desensitization and
downregulation in the acute care setting and discuss potential implications for therapy and future

Beta-blockers: current state of knowledge and perspectives

M Ogrodowczyk, K Dettlaff… - Mini reviews in medicinal …, 2016 - ingentaconnect.com
… It also has a direct vasodilating effect on the blood vessels, which can be related to the
agonistic effect on β 2adrenoceptors located in the vessels. The strongest betablocking effect is …

How Carvedilol activates β2-adrenoceptors

T Benkel, M Zimmermann, J Zeiner, S Bravo… - Nature …, 2022 - nature.com
present study, and the uncovered mechanism that carvedilol exerts its positive signalling
through β 2 … Notwithstanding these caveats, our new knowledge adds value to the future use of …

The β2-adrenergic receptor-ROS signaling axis: An overlooked component of β2AR function?

KM Rambacher, NH Moniri - Biochemical pharmacology, 2020 - Elsevier
… The β2-adrenergic receptor (β2AR), a prototype of the G protein-coupled receptor (GPCR) …
rapid bronchodilation and is therefore the current gold standard for therapeutic treatment of …

The Principles of Ligand Specificity on beta-2-adrenergic receptor

HCS Chan, S Filipek, S Yuan - Scientific reports, 2016 - nature.com
… fingerprint of the β 2 -adrenergic receptor (β 2 AR). β-adrenoceptors belong to rhodopsin-like …
& Matera, MG beta(2) -adrenoceptor agonists: current and future direction. British journal of …