Future perspectives of anticholinergics for the treatment of asthma in adults and children

R Buhl, E Hamelmann - Therapeutics and Clinical Risk …, 2019 - Taylor & Francis
… lung function and trends toward improved … current recommendations and recent developments
in asthma management; it also considers the role of anticholinergic therapy and the future

Design, synthesis and biological evaluation of 5-(2-amino-1-hydroxyethyl)-8-hydroxyquinolin-2 (1H)-one derivatives as potent β2-adrenoceptor agonists

G Xing, L Pan, C Yi, X Li, X Ge, Y Zhao, Y Liu… - Bioorganic & Medicinal …, 2019 - Elsevier
β 2 /β 1 -selectivity of the compounds in the present study was given by the pEC 50 at the β 2
-adrenoceptor minus the pEC 50 at the β 1 -adrenoceptor. … investigated in the present study. …

[HTML][HTML] β2-adrenoceptor signaling reduction in dendritic cells is involved in the inflammatory response in adjuvant-induced arthritic rats

H Wu, J Chen, S Song, P Yuan, L Liu, Y Zhang… - Scientific reports, 2016 - nature.com
… the present study, we investigated the effect of the β-AR agonist isoprenaline (ISO) on the
function of DCs, the impact of the β 2 -AR agonist … may be a direction for future research on RA. …

The β 2-Adrenergic agonist salbutamol inhibits migration, invasion and metastasis of the human breast cancer MDA-MB-231 cell line

EM Rivero, CP Pinero, L Gargiulo… - Current Cancer Drug …, 2017 - ingentaconnect.com
adrenergic action in breast cancer is controversial. We have previously shown that β-adrenergic
agonists … Objective: The purpose of the present investigation was to evaluate adrenergic

[HTML][HTML] Cardiovascular safety of β3-adrenoceptor agonists for the treatment of patients with overactive bladder syndrome

GM Rosa, S Ferrero, VW Nitti, A Wagg, T Saleem… - European urology, 2016 - Elsevier
adrenoceptor agonist) appears to be acceptable at therapeutic doses and comparable with
that of antimuscarinic agents, the current … analyzed in a detailed prospective analysis of the …

[HTML][HTML] In vitro anti-inflammatory effects of AZD8999, a novel bifunctional muscarinic acetylcholine receptor antagonist/β2-adrenoceptor agonist (MABA) compound in …

J Milara, S Contreras, A de Diego, M Calbet, M Aparici… - Plos one, 2019 - journals.plos.org
… , the concentrations used in previous studies were 100nM of salmeterol [29], 10nM aclidinium
[9] and 1nM of fluticasone propionate respectively, higher than those used in the present

The importance of muscarinic receptors in domestic animal diseases and therapy: Current and future perspectives

G Abraham - The Veterinary Journal, 2016 - Elsevier
… Despite the fact that there is still very limited evidence for the physiological role of nicotinic
receptors in mammals, these receptors will not be considered in this review. The muscarinic …

Development of covalent antagonists for β1-and β2-adrenergic receptors

T Schwalbe, H Huebner, P Gmeiner - Bioorganic & Medicinal Chemistry, 2019 - Elsevier
… We herein present the stereospecific synthesis of covalently … on the pharmacophores of
adrenergic β 1 - and β 2 receptor … future structural and functional studies on the β 1 AR and β 2

Personalized medicine with biologics for severe type 2 asthma: current status and future prospects

M Godar, C Blanchetot, H de Haard, BN Lambrecht… - MAbs, 2018 - Taylor & Francis
… Citation 4 In many patients, the disease can be controlled by a combination of nonspecific
drugs, an inhaled corticosteroid (ICS) and a short- or long-acting β 2 -adrenergic agonist (…

Aptamer BC007 for neutralization of pathogenic autoantibodies directed against G-protein coupled receptors: A vision of future treatment of patients with …

G Wallukat, J Müller, A Haberland, S Berg, A Schulz… - Atherosclerosis, 2016 - Elsevier
… Here we present first steps to introduce a recently identified aptamer [15] new named BC007,
for binding and neutralizing of all the GPCR-AABs presently known as pathogenic drivers …