[HTML][HTML] A pathogen-specific isotope tracing approach reveals metabolic activities and fluxes of intracellular Salmonella
K Mitosch, M Beyß, P Phapale, B Drotleff, K Nöh… - PLoS …, 2023 - journals.plos.org
… labeling strategies combined with mass spectrometry (MS) or … as inputs to the quantitative
13C flux modeling. Overall, our … patterns in the host–pathogen co-metabolism, we needed to …
13C flux modeling. Overall, our … patterns in the host–pathogen co-metabolism, we needed to …
[HTML][HTML] To eat and to be eaten: mutual metabolic adaptations of immune cells and intracellular bacterial pathogens upon infection
W Eisenreich, T Rudel, J Heesemann… - Frontiers in cellular and …, 2017 - frontiersin.org
… In vivo infection studies, combined with single cell analysis and sensitive techniques …
understanding of IBP infections, but may also reveal novel approaches to combat the often severe …
understanding of IBP infections, but may also reveal novel approaches to combat the often severe …
[HTML][HTML] Dissecting host-pathogen interactions in TB using systems-based omic approaches
… This proteomic analysis revealed different expression … Metabolomics combined with isotope
labelling strategies have … various host-pathogen models to measure intracellular metabolism …
labelling strategies have … various host-pathogen models to measure intracellular metabolism …
[PDF][PDF] Generalized and High-throughput ¹³C Metabolic Flux Ratio Analysis by Machine Learning
M Zimmermann-Kogadeeva - 2016 - research-collection.ethz.ch
… In summary, the developed targeted 13C flux ratio approach … metabolic fluxes32-36, measure
a vast variety of intracellular … In a study of host-pathogen interactions during early infection…
a vast variety of intracellular … In a study of host-pathogen interactions during early infection…
A mixed nitrogen diet and compartmentalized utilization for Mycobacterium tuberculosis replicating in host cells: results of a systems-based analysis
… 13C-Flux Spectral Analysis (FSA) based approach applied to the intracellular carbon metabolism
… Furthermore, our results revealed that 9 amino acids (Asn, Ile, Leu, Met, Lys, Tyr, Phe, …
… Furthermore, our results revealed that 9 amino acids (Asn, Ile, Leu, Met, Lys, Tyr, Phe, …
Bayesian multi-model-based 13C15N-metabolic flux analysis quantifies carbon-nitrogen metabolism in mycobacteria
… We also applied 13 C-MFA to quantify intracellular C fluxes … Our results reveal that the lack
of oleic acid as C source is … The lower and intermediate phase were mixed into one phase by …
of oleic acid as C source is … The lower and intermediate phase were mixed into one phase by …
Metabolic fluxes for nutritional flexibility of Mycobacterium tuberculosis
… W, McFadden J (2013) 13C-Flux spectral analysis of host-pathogen metabolism reveals
a mixed diet for intracellular Mycobacterium tuberculosis. Chem Biol 20: 1012–1021Crossref…
a mixed diet for intracellular Mycobacterium tuberculosis. Chem Biol 20: 1012–1021Crossref…
Contextual flexibility in Pseudomonas aeruginosa central carbon metabolism during growth in single carbon sources
… , our proteomic and transcriptomic analyses revealed a global … marked diauxy during growth
on mixed carbon sources (6). In vitro… is sufficient to alter the intracellular redox economy of P. …
on mixed carbon sources (6). In vitro… is sufficient to alter the intracellular redox economy of P. …
Metabolic adaptation of intracellular bacteria and fungi to macrophages
… transporters and metabolic adaptation. In this review, we discuss the metabolic adaptation
of facultative intracellular bacteria and fungi to the intracellular lifestyle inside macrophages. …
of facultative intracellular bacteria and fungi to the intracellular lifestyle inside macrophages. …
[HTML][HTML] Metabolic flux reprogramming in Mycobacterium tuberculosis-infected human macrophages
K Borah Slater, L Moraes, Y Xu, D Kim - Frontiers in Microbiology, 2023 - frontiersin.org
… Quantitative analysis in Figure 4 shows that the fractional abundance or … Host-pathogen
metabolic interactions are important in TB. … This study showed a reduced glycolytic extracellular …
metabolic interactions are important in TB. … This study showed a reduced glycolytic extracellular …