… We investigated the impact of the extracellular supplementation of 2,3-DPG on the … or
stress factors [27,28]. However, it can also be impacted by intrinsic or extrinsic host factors, as …

… As RBCs lack intracellular organelles, their primary source of energy is via anaerobic … 2-PG
is a physiological activator that exists in RBCs at a concentration of 2–5 µM [77]. A study …

… intracellular concentration of 2,3-diphosphoglycerate (2,3-DPG). 2,3-DPG is a glycolytic
intermediate 2 … intermediates, including 2,3-DPG, and deficiency of ATP, factors detrimental to …

… as this reduces 2,3-diphosphoglycerate (2,3-DPG) and increases ATP, factors that decrease
… Conversely, lowering intracellular 2,3-DPG levels decreases sickling of erythrocytes from …

… , especially 2,3diphosphoglycerate (2,3-DPG). Increased … , lowering 2,3-DPG levels is
accompanied by 3 other factors … in 2,3-DPG from 2 effects: an increase in intracellular pH40-42 …

… the effect of pH, carbon monoxide, and other factors on HbS … the pH effect showed that the
lowered pH over the physiological … effects of 2,3-diphosphoglycerate and intracellular pH on …

… In this graphic, factors that slow the transit of red cells through … allosteric effector for Hb is
2,3-diphosphoglycerate (2,3-DPG), … Over the physiologic intracellular pH range of 7.2 to 7.3, the …

… , sickle fiber destabilization by decreasing 2,3-diphosphoglycerate, altering the kinetics of
hemoglobin polymerization by decreasing the intracellular hemoglobin concentration through …

… Additionally, sickle RBCs have elevated 2,3-diphosphoglycerate (2,3-DPG) levels … Notably,
FT-4202 administration increased HbS O 2 affinity to levels well within the physiological range…

… the RBC concentration of 2,3-diphosphoglycerate (2,3-DPG), … /mL and converted to intracellular
concentrations by dividing … grade 2 hypertension and was possibly related to physiologic …