Chromatin reorganization governs gene expression regulation during pre-implantation
development. However, the global chromatin landscape and its dynamics in this period
remain unexplored in bovine. In this study, we constructed a genome-wide map of
accessible chromatin in bovine oocytes and early embryos using an improved assay for
transposase-accessible chromatin with high-throughput sequencing (ATAC-seq). We
analysed pools of 20 germinal vesicles or MII oocytes or 2-, 4-, 8-, 16-cell, morula, and …

Chromatin reorganization governs the regulation of gene expression during preimplantation
development. However, the landscape of chromatin dynamics in this period has not been
explored in bovine. In this study, we constructed a genome-wide map of accessible
chromatin in bovine oocytes and early embryos using an improved assay for transposase-
accessible chromatin with high-throughput sequencing (ATAC-seq) which revealed unique
features of the accessible chromatin during bovine early embryo development. We found …