Simple Summary The tumour microenvironment is composed of multiple non-cancerous
cells that communicate with the tumour cells, influencing their behaviour and impacting the
progression of the disease and the response to therapy. To better understand the disease
and try to predict the response of patients to therapy, there has been an effort to develop
experimental strategies that could represent this complex human tumour microenvironment
in a dish (in vitro). In this review, we describe the importance of each cell type and review the …

The tumour microenvironment plays a critical role in tumour progression and drug resistance
processes. Non-malignant cell players, such as fibroblasts, endothelial cells, immune cells
and others, interact with each other and with the tumour cells, shaping the disease. Though
the role of each cell type and cell communication mechanisms have been progressively
studied, the complexity of this cellular network and its role in disease mechanism and
therapeutic response are still being unveiled. Animal models have been mainly used, as …