The behavioral, pathological and therapeutic features of the triple transgenic Alzheimer's disease (3× Tg-AD) mouse model strain

S Tian, T Ye, X Cheng - Experimental Neurology, 2023 - Elsevier
… Although APP expression was not altered by age, monomers … in the hippocampus of a
3xTg-AD mouse were increasedlevel of low oligomer alone cannot alleviate the learning …

Aberrant Cortical Activity in 5xFAD Mice in Response to Social and Non-Social Olfactory Stimuli

F Kosel, MR Hartley, TB Franklin - Journal of Alzheimer's …, 2023 - content.iospress.com
… in 3xTg-AD mice, with transgenic (Tg) males exhibiting no … in the present study suggests
that these mice exhibit increased … suggesting that altered neural activity is due to -related …

[HTML][HTML] Impact of social isolation on the behavioral, functional profiles, and hippocampal atrophy asymmetry in dementia in times of coronavirus pandemic (COVID-19 …

A Muntsant, L Giménez-Llort - Frontiers in psychiatry, 2020 - frontiersin.org
… the impact of long-term isolation in male 3xTg-AD mice modeling … isolation in the AD pathology
as related to an increase in … -with-stress strategies were changed (from freeze) to flight …

[HTML][HTML] Environmental novelty exacerbates stress hormones and pathology in an Alzheimer's model

KE Stuart, AE King, CM Fernandez-Martos… - Scientific Reports, 2017 - nature.com
… , elevated stress levels, which may in turn have increased … APP/PS1 mice display
pathology from 4-5 months of age … novel enrichment objects (changed weekly). Housing …

[图书][B] Interleukin-6 trans-signaling in Alzheimer's disease. A study based on the Tg2576 and 3xTg-AD mouse models

A Escrig - 2019 - ddd.uab.cat
levels were diminished after the HFD treatment in comparison with mice fed with a
normal … There are evidences that altered insulin actions facilitate and tau accumulation. …

[HTML][HTML] Voluntary running does not reduce neuroinflammation or improve non-cognitive behavior in the 5xFAD mouse model of Alzheimer's disease

M Svensson, E Andersson, O Manouchehrian… - Scientific Reports, 2020 - nature.com
… Further, the inflammatory response is also altered in the AD … stress response in mice 34 , we
controlled for stress induction by … a nonsignificant trend towards increased plaques in the …

Endocannabinoid and muscarinic signaling crosstalk in the 3xTg-AD mouse model of Alzheimer's disease

A Llorente-Ovejero, I Manuel… - Journal of …, 2018 - content.iospress.com
elevated plus maze, and the dark/light box [20–23]. Interestingly, in 6-month-old 3xTg-AD
mice, the intraneuronal … signaling are altered in seven-month-old male 3xTg-AD mice, when …

[HTML][HTML] … , body/face interaction, and lack of barbering: sex-dependent behavioral signatures of social dysfunction in 3xTg-AD mice as compared to mice with normal …

V Torres-Lista, L Giménez-Llort - Journal of Alzheimer's …, 2019 - content.iospress.com
… engaged in active copying-with-stress strategies [22]. Here, … Therefore, when the previous
actions are altered, as it is the … anxious-like profile exhibited since young adulthood [8]. Several …

[HTML][HTML] … Against Brain Amyloid-β1–42 Accumulation in Female Mice with Early Alzheimer's Disease-Like Pathology by Partially Rescuing Oxidative/Nitrosative Stress …

AI Duarte, E Candeias, IN Alves, D Mena… - International journal of …, 2020 - mdpi.com
… observed a significant increase in brain 1–42 , 1–40 … and p-tau content in 11-month-old
3xTg-AD female mice (in … properties) and by altering mitochondrial dynamics, ultimately …

[HTML][HTML] Neuropathological and behavioral features of an APP/PS1/MAPT (6xTg) transgenic model of Alzheimer's disease

SH Tag, B Kim, J Bae, KA Chang, HI Im - Molecular Brain, 2022 - Springer
… On the other hand, AD-related presenilin mutations can alter … APP/PS1, 3xTg-AD, and
5xFAD mouse models of AD have … that can rapidly manifest both the plaques and NFTs is …