[HTML][HTML] Transgenic autoinhibition of p21-activated kinase exacerbates synaptic impairments and fronto-dependent behavioral deficits in an animal model of …
C Bories, D Arsenault, M Lemire, C Tremblay… - Aging (Albany …, 2017 - ncbi.nlm.nih.gov
… PAK combined with Aβ and tau pathologies (3xTg-AD mice) in … At the behavior level, we
focused on anxiety and social … Pyramidal cell morphology is altered in 3xTg-AD mice with …
focused on anxiety and social … Pyramidal cell morphology is altered in 3xTg-AD mice with …
Therapeutic targeting of casein kinase 1δ/ε in an Alzheimer's disease mouse model
… their efficacy in reducing Aβ levels and enhancing memory in … it was not altered by PF-670462,
with 3xTg-AD mice in both … can re-establish normal behavioral circadian rhythms when …
with 3xTg-AD mice in both … can re-establish normal behavioral circadian rhythms when …
The involvement of homocysteine in stress-induced Aβ precursor protein misprocessing and related cognitive decline in rats
F Xie, Y Zhao, J Ma, JB Gong, SD Wang… - Cell Stress and …, 2016 - Springer
… received chronic unexpected mild stress (CUMS) by behavioral … One of the following stressors
was administered daily (in … here, and the alteration of Hcy level in cerebrospinal fluid was …
was administered daily (in … here, and the alteration of Hcy level in cerebrospinal fluid was …
[HTML][HTML] FAK-mediated signaling controls amyloid beta overload, learning and memory deficits in a mouse model of Alzheimer's disease
B Saleh, KD Srikanth, T Sneh, L Yue, S Pelech… - International Journal of …, 2022 - mdpi.com
… changes that occur in our 3xTg-AD mice, we performed an … /or to the increase in Aβ plaque
production in these mice as … accompanied by Aβ overload, altered neuronal morphology, and …
production in these mice as … accompanied by Aβ overload, altered neuronal morphology, and …
[HTML][HTML] Repetitive Low-Level Blast Exposure Improves Behavioral Deficits and Chronically Lowers Aβ42 in an Alzheimer Disease Transgenic Mouse Model
GP Garcia, R De Gasperi, AE Tschiffely… - Journal of …, 2021 - ncbi.nlm.nih.gov
… enzymes may cause increased Aβ production and explain the … show that repetitive exposures
actually improved behavioral … not alter amyloid plaque load, Aβ 42 levels and Aβ oligomers …
actually improved behavioral … not alter amyloid plaque load, Aβ 42 levels and Aβ oligomers …
Involvement of brain-derived neurotrophic factor signaling in the pathogenesis of stress-related brain diseases
T Numakawa, R Kajihara - Frontiers in Molecular Neuroscience, 2023 - frontiersin.org
… between the alteration of TrkB signaling and chronic stress. … Increased glucocorticoids due
to sustained activation of the HPAaxis contribute to Aβ and/or tau pathology, oxidative stress, …
to sustained activation of the HPAaxis contribute to Aβ and/or tau pathology, oxidative stress, …
[HTML][HTML] Old maids: aging and its impact on microglia function
… in Aβ plaque deposition, CX3CR1-deficient mice exhibited … old 3xTg-AD mice, without having
any overt effect on behavior or … Germ-free mice exhibited altered microglia morphology and …
any overt effect on behavior or … Germ-free mice exhibited altered microglia morphology and …
[HTML][HTML] … -phenotype, HPA axis, splenic oxidative stress and frailty in late-stages of dementia, with special concerns on the effects of social isolation: a translational …
A Muntsant, L Giménez-Llort - Frontiers in Aging Neuroscience, 2022 - frontiersin.org
… behavioral alterations in 18-month-old female 3xTg-AD mice … an altered response in the
3xTg-AD mice characterized by a … short isolation could increase the activity in 3xTg-AD mice and …
3xTg-AD mice characterized by a … short isolation could increase the activity in 3xTg-AD mice and …
[HTML][HTML] Behavioural Phenotyping of APPswe/PS1δE9 Mice: Age-Rrelated Changes and Effect of Long-Term Paroxetine Treatment
LØ Olesen, EV Bouzinova, M Severino… - PLoS …, 2016 - journals.plos.org
… AD transgenic mouse model (3xTgAD) [18], which also exhibits … There was no correlation
between Aβ plaque load and ‘Total … -like behavior is paired to monoaminergic alteration in a …
between Aβ plaque load and ‘Total … -like behavior is paired to monoaminergic alteration in a …
Noise exposure accelerates the risk of cognitive impairment and Alzheimer's disease: Adulthood, gestational, and prenatal mechanistic evidence from animal studies
… and increases stress hormones that affect brain and behaviour. … High levels of corticosterone
days after NS, and changes in … the stress literature, chronic exposure to high levels of stress …
days after NS, and changes in … the stress literature, chronic exposure to high levels of stress …