[PDF][PDF] β-Arrestin coupling to Purinergic Receptors: Glo with the Flow?

J Storme - 2018 - biblio.ugent.be
cystic fibrosis transmembrane conductance regulator CNS … The β2-adrenergic receptor
(β2AR) was cloned a few years … binding region concerns a C-terminal motif (LIEF; residues 373-…

Role of the P2Y1 receptor in platelet activation

TN Blatt - 2016 - search.proquest.com
… and binds to the phosphorylated C-terminal residues on rhodopsin, … is a 4 amino acid (aa)
motif on the distal C-terminus that … ; these motifs have been observed on both the β2adrenergic

Characterization of the Βeta2-Adrenergic Receptor's Cysteine Redox Mediated Effects on Ligand Binding and Canonical Signaling

KM Rambacher - 2019 - search.proquest.com
… Moniri Inhaled β2-adrenergic receptor (β2AR) agonists are … found in retinal rods and cones,
the β-adrenergic receptor … N-terminal glycosylation and C-terminal palmitoylation as well …

Characteristics and the role of purinergic receptors in pathophysiology with focus on immune response: purinergic receptors are widely expressed in immune cells …

M Zyma, R Pawliczak - International Reviews of Immunology, 2020 - Taylor & Francis
… and COOH terminus that have motifs to bind protein kinases, … receptors can interact with A
2A and P2Y 1 , P2Y 2 receptors. … in pulmonary fibrosis (SPP1 and APEG) after A 3 receptor

[HTML][HTML] G protein-coupled receptors (GPCRs): advances in structures, mechanisms, and drug discovery

M Zhang, T Chen, X Lu, X Lan, Z Chen… - Signal Transduction and …, 2024 - nature.com
… and the ligand-activated β2 adrenergic receptor (β2AR) were … The phosphorylation of the
receptor C-terminal tail by GRK … motifs relevant to their activation, including the CWxP motif of …

[HTML][HTML] Structural diversity of leukotriene G-protein coupled receptors

A Luginina, A Gusach, E Lyapina, P Khorn… - Journal of Biological …, 2023 - Elsevier
… and COPD, rheumatoid arthritis, cystic fibrosis, diabetes, and … R) and purinergic (eg P2Y 1
R) receptors, with the ligands of … -terminal Flag tag and a C-terminal 6xHis tag separated by a …

Heterotrimeric G proteins as therapeutic targets in drug discovery

J Li, Y Ge, JX Huang, K Strømgaard… - Journal of Medicinal …, 2019 - ACS Publications
… as tool compounds are available. Another reason that G … G protein regulatory (GPR)/GoLoco
motif was identified in … aggregation mediated by the ADP receptor P2Y1 with an IC 50 …

Medicinal Receptors Chemistry of A2B Adenosine

CE Müller, Y Baqi, S Hinz… - … Adenosine Receptors, 2018 - books.google.com
… not dependent on the long C-terminal tail of the A2AAR since … macrophages and contributes
to pulmonary fibrosis. FASEB J … , the β2-adrenergic receptor and the human adenosine A2A …

Medicinal Chemistry of A2B Adenosine Receptors

CE Müller, Y Baqi, S Hinz, V Namasivayam - The adenosine receptors, 2018 - Springer
… on the long C-terminal tail of the A 2A AR since truncation did not affect heteromerization
and was also found to be independent of the presence of receptor agonists or antagonists. Co-…

[HTML][HTML] Synthesis and Pharmacological Studies of pH-Sensitive, Allosteric, and Bivalent Ligands as Modulators of GPCRs

R Rosas Jr - 2021 - search.proquest.com
… DNA of the β2-adrenergic receptor that researchers observed the … An additional conserved
structural motif observed in some … the β2-adrenergic, adenosine A1, P2Y1, and dopamine D2 …