… inhibition, spontaneous reactivation and aging reaction are taking place simultaneously or
with or without chemical hydrolysis of the inhibitor [7,… kinetic model of simultaneous inhibition, …

… , we evaluated the kinetics of inhibition, reactivation, and aging of PHO using recombinant
… utilized to study the toxicity of OP compounds and five oximes that are currently fielded (or …

… reactivation or aging processes. We initially approached the adduct fate inquiry by employing
in vitro kinetic … adduct reactivation processes relative to the competitive aging mechanism. …

… In the present study we investigated the reactivation kinetics of four structurally related
non-oxime compounds with human AChE inhibited by the nerve agents sarin, cyclosarin, VX and …

… the effect of six quaternary ammoniums on the aging kinetics of sarin.13 Among them, 0.1 …
reactivation of inhibited AChE, considering the fast aging and slow spontaneous reactivation of …

… of the CatA active site that favor spontaneous reactivation at low pH and aging at neutral pH.
… To compare the relative rates of inhibition, we measured the kinetic parameters of inhibition …

… points, and kinetic calculations were used to obtain their spontaneous reactivation (Ks) and
aging (Ka) … The mechanism of the interaction between organophosphorus agents and AChE (…

… Pathways of inhibition, reactivation and aging of AChE following … Reactivation kinetics at
different OP exposure times (15 min … for their ability to reactivate AChE inhibited by different OPs. …

… PiMP) was prepared via two rounds of aging, considering the chirality of PiMP. We … aging,
in order to reactivate any residual inhibited AChE. Then, PiMP was added to inhibit and age …

… When AChE is inhibited by OPs, its reactivation can be … complete effective reactivation activity
for AChE inhibited by any of … very fast aging, there is no oxime capable of reactivation [38]. …