[HTML][HTML] The utility of HepaRG cells for bioenergetic investigation and detection of drug-induced mitochondrial toxicity

L Kamalian, O Douglas, CE Jolly, J Snoeys, D Simic… - Toxicology in Vitro, 2018 - Elsevier
… Pioglitazone and amiodarone were excluded from this study due to inconsistent solubility
in … and perhexiline showed decrease of SRC with or without ALR, but with concomitant

Hepatotoxicity by drugs

AC Paniagua, P Amariles - … and Adverse Effects of Drugs …, 2017 - books.google.com
… factors such as concomitant administration of drugs or herbal remedies, alcohol consumption,
… present, RUCAM allows discern when confusing factors or concomitant drugs are present. …

Evidence-based selection of training compounds for use in the mechanism-based integrated prediction of drug-induced liver injury in man

S Dragovic, NPE Vermeulen, HH Gerets, PG Hewitt… - Archives of …, 2016 - Springer
… ; amiodarone, perhexiline, and troglitazone on causing lysosomal impairment and bosentan,
diclofenac, nefazodone, perhexiline, … steatosis, concomitant macrovacuolar steatosis and …

Drug-Induced Fatty Liver Disease (DIFLD): A Comprehensive Analysis of Clinical, Biochemical, and Histopathological Data for Mechanisms Identification and …

E López-Pascual, I Rienda, J Perez-Rojas… - International Journal of …, 2024 - mdpi.com
… In certain individuals, drug-induced steatosis is often accompanied by concomitant injury …
occasionally reported for drugs such as amiodarone, perhexiline, and didanosine [13,37]. …

Inhibition of mitochondrial fatty acid oxidation in drug-induced hepatic steatosis

B Fromenty - Liver Research, 2019 - Elsevier
perhexiline and pirprofen were withdrawn after marketing. (ii) Drugs such as amiodarone and
perhexiline … (iii) For some drugs including APAP, 40 , 41 L-asparaginase, 42 erythromycin, …

Drug-induced steatohepatitis

A Dash, RA Figler, AJ Sanyal… - Expert opinion on drug …, 2017 - Taylor & Francis
Amiodarone and perhexiline are both known to induce phospholipidosis [Citation6,Citation7…
could potentially impact the effects of concomitant steatohepatitic drugs. CYP2E1 can impair …

Towards personalized management of drug interactions: from drug-drug-interaction to drug-drug-gene-interaction

A Bahar - 2020 - research.rug.nl
… using lansoprazole and warfarin concomitantly had a greater … CYP2D6 inhibitors (terbinafine,
perhexiline, and quinidine) … Additionally, amiodarone and celecoxib in their interactions …

[HTML][HTML] Nomenclature, diagnosis and management of drug-induced autoimmune-like hepatitis (DI-ALH): an expert opinion meeting report

RJ Andrade, GP Aithal, YS De Boer, R Liberal… - Journal of …, 2023 - Elsevier
… as malignancy or DILI due to another concomitant drug. ChILI shows less … case of possible
AIH related to SARS-CoV-2 vaccination was published. Several case reports and case series

Phenoconversion of cytochrome P450 metabolism: a systematic review

SD Klomp, ML Manson, HJ Guchelaar… - Journal of Clinical …, 2020 - mdpi.com
… started therapy with the weak CYP2D6 inhibitor amiodarone [… , the drug interaction with
amiodarone would have had a … the effect of (1) concomitant drugs and other extrinsic factors …

Iatrogenic immune-mediated neuropathies: diagnostic, epidemiological and mechanistic uncertainties for causality and implications for clinical practice

HS Goedee, S Attarian, T Kuntzer… - Journal of Neurology …, 2021 - jnnp.bmj.com
report suggested possible relation of GBS after surgery, but establishing possible causal
relation in this case series … antecedent infections, and concomitant use of drugs (eg, tacrolimus …