Impairment of anti-aggregatory responses to nitric oxide and prostacyclin: Mechanisms and clinical implications in cardiovascular disease

YY Chirkov, TH Nguyen, JD Horowitz - International Journal of Molecular …, 2022 - mdpi.com
… 2 is exaggerated in the presence of concomitant obesity [78]. An … ACS [130], that therapy
with perhexiline for three days was … also occurred after perhexiline therapy in patients with SAP …

Predictive value of cellular accumulation of hydrophobic bile acids as a marker of cholestatic drug potential

A Burban, A Sharanek, L Humbert… - Toxicological …, 2019 - academic.oup.com
… and profile induced by cholestatic drugs in human liver. In this study, we aimed to analyze
the effects of a large set of cholestatic and noncholestatic drugs in presence of physiological …

Pure autonomic failure and the differential diagnosis of autonomic peripheral neuropathies

A González-Duarte, A Varma-Doyle… - Current Opinion in …, 2021 - journals.lww.com
… Subclinical or clinically evident hyposmia is a frequent concomitant feature in PAF patients
[… include the antiarrhythmic agent, amiodarone, the coronary vasodilator, perhexiline, and the …

Side effects of beta adrenergic antagonists and antianginal drugs

LM Stever, AN Ali, LB Chambers… - Side Effects of Drugs …, 2022 - Elsevier
… This case report suggests that medication therapy may not … to elucidate the mechanism of
perhexiline's toxicity in human … He was taking amiodarone and pravastatin for 1 year which …

[HTML][HTML] Cardiac autonomic neuropathy: Risk factors, diagnosis and treatment

VA Serhiyenko, AA Serhiyenko - World journal of diabetes, 2018 - ncbi.nlm.nih.gov
… of diabetic dyslipidemia (DLP); antioxidants; vitamins; treatment of myocardial metabolic
abnormalities; thrombosis; management of OH; symptomatic treatment of concomitant diseases …

Clinical consequences of drug-induced mitochondrial dysfunction

RL Jensen, RT Kiy, FFB Dayel, AE Chadwick - Mitochondrial Intoxication, 2023 - Elsevier
… Research has shown that drugs such as perhexiline, amiodarone, and tamoxifen can
accumulate in the mitochondria and can interfere with some processes including the electron …

Drug Deaths

OH Drummer - Forensic and Legal Medicine, 2024 - taylorfrancis.com
… This type of drug toxicity occurs when two or more drugs capable of increasing serotonin
levels in nerve terminals are used concomitantly (18). A large number of drugs have “serotonin” …

Targeting the cellular schizophrenia. Likely employment of the antipsychotic agent pimozide in treatment of refractory cancers and glioblastoma

I Elmaci, MA Altinoz - Critical Reviews in Oncology/Hematology, 2018 - Elsevier
… The remaining compounds consist of five agents, including three FDA-approved drugs for
cardiovascular indications, niguldipine, nicardipine and amiodarone, that inhibit intracellular …

Autophagy regulation in the development and treatment of breast cancer

Y Zhou, EB Rucker III, BP Zhou - Acta biochimica et biophysica …, 2016 - academic.oup.com
… This dissociation event results in the dephosphorylation of inhibitory sites of Ulk1/2 and
autophosphorylation of its activating sites, which leads to concomitant activation of its interacting …

Steatosis, Steatohepatitis and Cancer Immunotherapy: An Intricate Story

M Cataldi, F Manco, G Tarantino - International Journal of Molecular …, 2021 - mdpi.com
drugs that cause steatosis and steatohepatitis independently from any concomitant
triggering factor (eg, amiodarone and perhexiline maleate); and 3. …