… simplifies the causal diagram and reduces sources of potential bias. … Now, we focus on
modeling the tissue epigenotype as the outcome to understand the role cellular heterogeneity …

… a major caveat of heterogeneity in the cellular composition of … The strong bias towards
cell type-specific H3K27ac regions … fold of change in all peaks overlapping with a cell type-specific …

… Brain tissue studies are challenged by small sample sizes of cases and controls, incomplete
phenotyping, post-mortem timing, and cellular heterogeneity, … Further, there may be bias in …

… We conclude that sample heterogeneity masks … particular, we suggest that exploitation of
the single-cell composition of the epigenome will provide important insights into heterogeneity …

… control of cellular heterogeneity in epigenetic studies of brain … that some cell types were
associated with a particular bias in … < 5 × 10 −3 , corrected for 10 cell types) for the prevalence of …

… not account for the high cellular heterogeneity in the brain. This can … cell epigenotype specific
model for the correction of brain cellular heterogeneity bias and its application to age, brain …

… Third, we applied genomic control corrections to the meta-… SNPs that exhibited substantial
heterogeneity across studies … to detect and correct for the bias due to directional pleiotropy 41 . …

… the cellular heterogeneity and complexity of the brain is … -based algorithm, cell epigenotype
specific (CETS) marks, to … , including artificial bias in counting the cells and the destruction of …

… less than 18, to limit heterogeneity due to differences between the mature and developing
brain. … and to develop models to deconvolve the cell-type specific regulatory effects in different …

… boundaries change in older human brains and buccal cells. … the cellular heterogeneity
problem is either by flow sorting the … for ascertainment bias and confounding cellular composition …