… In different protein design tasks, it is often common requisites … interactions in failed
protein–protein interface designs, while … between inter-solute hydrogen bonding and desolvation …

… locked in inter-residual hydrogen bonding network, with α -… module of DNA binding protein
Zif268 highlighting the residues (… burial benefit and a polar-burial penalty in the protein-design …

… buried polar interactions at the cage–latch or cage–key … results highlight the potential of de
novo protein design to … Unless otherwise indicated, data are shown as mean ± sd, and error …

… In order to facilitate this search, we focused on designing a … ), or residues that are buried in
the protein core (purple). The … Although this made its characterization challenging, we were …

… highlight some of the key areas in modern drug design for … , for which most basic residues
were buried and not accessible for … ionic interactions and neutral hydrogen bonds can stabilize …

… ), highlighting its predictive power for ranking designs during … of different interactions (hydrogen
bonds, electrostatic and … ) a more buried catalytic residue (7 Å deeper into the protein …

… that buried and interfacial hydrogen bonds are pivotal for oligomerization. … This study
highlights the need to carefully design the … science highlights success stories rather than failures. …

… state it would be making a hydrogen bond. We will refer to such atoms as buried unsats. …
Plotted is the error in recovery when 3BOP was enabled. The general trend is that the more …

… the protein surface, whereas loops deeply buried in the protein … This highlights both the
powerful capability of Rosetta in … number of hydrogen bonds revealed differences for specific …

… protein function is widespread in biology, but is challenging … to design interfaces containing
buried hydrogen-bond networks; … cells, which highlights the modularity and utility of LOCKR. …