A computational analysis of in vivo VEGFR activation by multiple co-expressed ligands

LE Clegg, F Mac Gabhann - PLoS computational biology, 2017 - journals.plos.org
… factor to VEGF receptors, both on endothelial cells and soluble … bind to VEGF-receptor 1
(VEGFR1) and VEGF-receptor 2 (… included PlGF in a compartment model, PlGF binding to …

A multiscale computational model predicts distribution of anti-angiogenic isoform VEGF165b in peripheral arterial disease in human and mouse

LH Chu, VC Ganta, MH Choi, G Chen, SD Finley… - Scientific reports, 2016 - nature.com
… The existence of anti-angiogenic isoform (VEGF 165b ) in PAD … the three-compartment model
of VEGF distribution to predict … VEGF and soluble VEGF receptor-1 (sFlt-1) distributions in …

Immune cells regulate VEGF signalling via release of VEGF and antagonistic soluble VEGF receptor-1

T Hoeres, M Wilhelm, M Smetak… - Clinical & …, 2018 - academic.oup.com
VEGF can, in turn, be antagonized by soluble VEGF receptor … on stimulatory conditions
and the presence of monocytes. … we characterize VEGF production by blood-derived human

Positive and negative regulation of angiogenesis by soluble vascular endothelial growth factor receptor-1

CM Failla, M Carbo, V Morea - International Journal of Molecular …, 2018 - mdpi.com
… abnormal blood vessel formation, indicating that the presence of VEGFR-1 extracellular region
anchored … -A induction, mechanical forces downregulate sVEGFR-1 expression by human

Therapeutic implication of vascular endothelial growth factor receptor-1 (VEGFR-1) targeting in cancer cells and tumor microenvironment by competitive and non …

PM Lacal, G Graziani - Pharmacological research, 2018 - Elsevier
… In humans, VEGF-A 165 is the predominantly expressed … intracellular regions, secreted as
soluble forms that can be also … cell migration and modulates the distribution of leukemia blasts …

VEGF-A splice variants bind VEGFRs with differential affinities

SB Mamer, A Wittenkeller, PI Imoukhuede - Scientific reports, 2020 - nature.com
… to help further our understanding of angiogenic signaling in human health and pathology. …
in their presence could be accomplished by performing SPR experiments in the presence of …

Trafficking dynamics of VEGFR1, VEGFR2, and NRP1 in human endothelial cells

S Sarabipour, K Kinghorn, KM Quigley… - PLoS computational …, 2024 - journals.plos.org
… which we focus on here, and a soluble form (sVEGFR1 or sFlt) [… we quantified VEGF receptor
trafficking rates and distribution in … The presence of the complex also partly explains the low …

[HTML][HTML] The VEGF rise in blood of bevacizumab patients is not based on tumor escape but a host-blockade of VEGF clearance

L Alidzanovic, P Starlinger, D Schauer, T Maier… - Oncotarget, 2016 - ncbi.nlm.nih.gov
… on the presence of the heparin binding domain, are known as primarily soluble and diffusible
isoforms (VEGF-… Furthermore, by in vitro analyses with human cell cultures and tissues, we …

Role of VEGFs/VEGFR-1 signaling and its inhibition in modulating tumor invasion: experimental evidence in different metastatic cancer models

C Ceci, MG Atzori, PM Lacal, G Graziani - International journal of …, 2020 - mdpi.com
… of the VEGF family, named after its cloning from a human … (RTKs), including vascular
endothelial growth factor receptor 1 (… The VEGFR-1 is also secreted in the ECM as a soluble

Biophysical studies of the induced dimerization of human VEGF receptor 1 binding domain by divalent metals competing with VEGF-A

JF Gaucher, M Reille-Seroussi, N Gagey-Eilstein… - PLoS …, 2016 - journals.plos.org
… that human VEGFR1 domain 2 crystallizes in the presence of … , the soluble form (sFlt-1) of
the VEGFR1 sequesters VEGF-A … The distance pair-distribution functions were calculated from …