Non-human primate models of PD to test novel therapies

M Morissette, T Di Paolo - Journal of Neural Transmission, 2018 - Springer
Non-human primate (NHP) models of Parkinson disease show many similarities … dyskinesias
appear in most patients after chronic treatment and may become disabling. Dyskinesias are …

Pathophysiology of dyskinesia and behavioral disorders in non-human primates: the role of serotonergic fibers

V Sgambato, L Tremblay - Journal of Neural Transmission, 2018 - Springer
… To evaluate the severity of motor symptoms, different scales have been developed, eg,
eight scales in the macaque (Imbert et al. 2000). These scales include different behavioral …

The rodent models of dyskinesia and their behavioral assessment

Q Peng, S Zhong, Y Tan, WQ Zeng, J Wang… - Frontiers in …, 2019 - frontiersin.org
… severity over time in the non-human primate models. Although … dyskinetic features but less
rotation behavior are presented in … behavioral assessment methods and rating scales need to …

Animal models of l‐dopa‐induced dyskinesia in Parkinson's disease

MA Cenci, AR Crossman - Movement Disorders, 2018 - Wiley Online Library
… Soon after the introduction of MPTP primate models of PD it became … A variety of scales have
been developed to rate l-dopa-… , termed the Non Human Primate Dyskinesia Rating Scale. …

Validation of an improved scale for rating l-DOPA-induced dyskinesia in the mouse and effects of specific dopamine receptor antagonists

I Sebastianutto, N Maslava, CR Hopkins… - Neurobiology of …, 2016 - Elsevier
… previously found effective in both non-human primate and … were assessed using Pearson's
r (presented as r 2 values) and … non-human primate models of PD is based on rating scales

Pathophysiology of levodopa-induced dyskinesia: Insights from multimodal imaging and immunohistochemistry in non-human primates

M Beaudoin-Gobert, E Météreau, S Duperrier… - Neuroimage, 2018 - Elsevier
… For that purpose, we used our previous monkey model of PD presenting a double … analysis
(see supplementary data). Given the challenges to face research with non-human primates in …

Research advances on L-DOPA-induced dyskinesia: from animal models to human disease

X Chen, Y Wang, H Wu, C Cheng, W Le - Neurological Sciences, 2020 - Springer
… such rating scales by presenting specifics on the Non-Humannon-human primate dyskinesia
rating method, using a video-based scoring system, termed Quantitative Dyskinesia Scale (…

Models of hyperkinetic disorders in primates

E Bezard - Journal of Neuroscience Methods, 2020 - Elsevier
… in non-human primates. These disabling conditions include notably L-dopa-induced dyskinesia
in Parkinson’s disease, tardive dyskinesia… other conditions presented in this short review, …

Dyskinesia and Parkinson's disease: animal model, drug targets, and agents in preclinical testing

V Cesaroni, F Blandini, S Cerri - Expert Opinion on Therapeutic …, 2022 - Taylor & Francis
… We have also carried out a literature review reporting the … a novel non-human primate
dyskinesia rating method, using … Although many objective rating scales have been developed to …

Dopamine D3 receptor ligand suppresses the expression of levodopa-induced dyskinesia in nonhuman primate model of parkinson's disease

T Oh, ES Daadi, J Kim, EW Daadi, PJ Chen… - Experimental …, 2022 - Elsevier
… To measure dyskinesia we used Dyskinesia disability rating scale that is scored for different
… A) & C) Quantitative analysis of sleep quality parameters showed that dyskinetic marmosets …