Non-human primate models of PD to test novel therapies
M Morissette, T Di Paolo - Journal of Neural Transmission, 2018 - Springer
… Non-human primate (NHP) models of Parkinson disease show many similarities … dyskinesias
appear in most patients after chronic treatment and may become disabling. Dyskinesias are …
appear in most patients after chronic treatment and may become disabling. Dyskinesias are …
Pathophysiology of dyskinesia and behavioral disorders in non-human primates: the role of serotonergic fibers
V Sgambato, L Tremblay - Journal of Neural Transmission, 2018 - Springer
… To evaluate the severity of motor symptoms, different scales have been developed, eg,
eight scales in the macaque (Imbert et al. 2000). These scales include different behavioral …
eight scales in the macaque (Imbert et al. 2000). These scales include different behavioral …
The rodent models of dyskinesia and their behavioral assessment
Q Peng, S Zhong, Y Tan, WQ Zeng, J Wang… - Frontiers in …, 2019 - frontiersin.org
… severity over time in the non-human primate models. Although … dyskinetic features but less
rotation behavior are presented in … behavioral assessment methods and rating scales need to …
rotation behavior are presented in … behavioral assessment methods and rating scales need to …
Animal models of l‐dopa‐induced dyskinesia in Parkinson's disease
MA Cenci, AR Crossman - Movement Disorders, 2018 - Wiley Online Library
… Soon after the introduction of MPTP primate models of PD it became … A variety of scales have
been developed to rate l-dopa-… , termed the Non Human Primate Dyskinesia Rating Scale. …
been developed to rate l-dopa-… , termed the Non Human Primate Dyskinesia Rating Scale. …
Validation of an improved scale for rating l-DOPA-induced dyskinesia in the mouse and effects of specific dopamine receptor antagonists
I Sebastianutto, N Maslava, CR Hopkins… - Neurobiology of …, 2016 - Elsevier
… previously found effective in both non-human primate and … were assessed using Pearson's
r (presented as r 2 values) and … non-human primate models of PD is based on rating scales …
r (presented as r 2 values) and … non-human primate models of PD is based on rating scales …
Pathophysiology of levodopa-induced dyskinesia: Insights from multimodal imaging and immunohistochemistry in non-human primates
M Beaudoin-Gobert, E Météreau, S Duperrier… - Neuroimage, 2018 - Elsevier
… For that purpose, we used our previous monkey model of PD presenting a double … analysis
(see supplementary data). Given the challenges to face research with non-human primates in …
(see supplementary data). Given the challenges to face research with non-human primates in …
Research advances on L-DOPA-induced dyskinesia: from animal models to human disease
X Chen, Y Wang, H Wu, C Cheng, W Le - Neurological Sciences, 2020 - Springer
… such rating scales by presenting specifics on the Non-Human … non-human primate dyskinesia
rating method, using a video-based scoring system, termed Quantitative Dyskinesia Scale (…
rating method, using a video-based scoring system, termed Quantitative Dyskinesia Scale (…
Models of hyperkinetic disorders in primates
E Bezard - Journal of Neuroscience Methods, 2020 - Elsevier
… in non-human primates. These disabling conditions include notably L-dopa-induced dyskinesia
in Parkinson’s disease, tardive dyskinesia… other conditions presented in this short review, …
in Parkinson’s disease, tardive dyskinesia… other conditions presented in this short review, …
Dyskinesia and Parkinson's disease: animal model, drug targets, and agents in preclinical testing
V Cesaroni, F Blandini, S Cerri - Expert Opinion on Therapeutic …, 2022 - Taylor & Francis
… We have also carried out a literature review reporting the … a novel non-human primate
dyskinesia rating method, using … Although many objective rating scales have been developed to …
dyskinesia rating method, using … Although many objective rating scales have been developed to …
Dopamine D3 receptor ligand suppresses the expression of levodopa-induced dyskinesia in nonhuman primate model of parkinson's disease
T Oh, ES Daadi, J Kim, EW Daadi, PJ Chen… - Experimental …, 2022 - Elsevier
… To measure dyskinesia we used Dyskinesia disability rating scale that is scored for different
… A) & C) Quantitative analysis of sleep quality parameters showed that dyskinetic marmosets …
… A) & C) Quantitative analysis of sleep quality parameters showed that dyskinetic marmosets …