Classic animal models of Parkinson's disease: A historical perspective
A Hamadjida, I Frouni, C Kwan… - Behavioural …, 2019 - journals.lww.com
… in animal models of PD, while drugs found to be ineffective in experimental models, or …
primate (NHP) will be the focus of the current article (Table 1). We will, however, start this review …
primate (NHP) will be the focus of the current article (Table 1). We will, however, start this review …
Combined mGlu2 orthosteric stimulation and positive allosteric modulation alleviates l-DOPA-induced psychosis-like behaviours and dyskinesia in the parkinsonian …
SG Nuara, A Hamadjida, C Kwan, D Bédard… - Journal of Neural …, 2020 - Springer
… of PD, the parkinsonian non-human primate, which has high … On each of these scales, the
higher the score, the greater the … parkinsonism, dyskinesia, and PLB scores are presented as …
higher the score, the greater the … parkinsonism, dyskinesia, and PLB scores are presented as …
Further characterisation of psychosis-like behaviours induced by L-DOPA in the MPTP-lesioned marmoset
C Kwan, SG Nuara, JC Gourdon, P Huot - … -Schmiedeberg's Archives of …, 2021 - Springer
… The parkinsonian disability rating scale is presented in Table … From the analysis of the
PLBs, we also observed that … conducted in this small primate. These additions to the existing …
PLBs, we also observed that … conducted in this small primate. These additions to the existing …
The MPTP-lesioned marmoset model of Parkinson's disease: proposed efficacy thresholds that may potentially predict successful clinical trial results
… To do so, we used the evidence-based medicine reviews … lesioned marmoset and identified
articles reporting the effects of drugs that … For the treatment of dyskinesia, we suggest that the …
articles reporting the effects of drugs that … For the treatment of dyskinesia, we suggest that the …
Serotonergic innervation of the striatum in a nonhuman primate model of Parkinson's disease
L Jiménez-Sánchez, J Blesa, NL Del Rey… - …, 2020 - Elsevier
… in both PD and experimental parkinsonism in non-human primates, … Our stereological analysis
did not find any changes in 5-HT+ … Finally, we found no statistical correlation between the …
did not find any changes in 5-HT+ … Finally, we found no statistical correlation between the …
Monoamine oxidase A inhibition with moclobemide enhances the anti-parkinsonian effect of L-DOPA in the MPTP-lesioned marmoset
A Hamadjida, SG Nuara, C Kwan, I Frouni… - Naunyn-Schmiedeberg's …, 2020 - Springer
… dyskinesia score at any time point is 12. In A, data are presented as the median; in B, data are
presented … striatal dopamine in human and non-human primate (Riederer and Laux 2011), …
presented … striatal dopamine in human and non-human primate (Riederer and Laux 2011), …
Drug-induced dyskinesia, part 1: treatment of levodopa-induced dyskinesia
D Vijayakumar, J Jankovic - Drugs, 2016 - Springer
… Scale (UDysRS) is considered superior to other scales for … Although early introduction of
dopamine agonists may be … Topiramate was shown in rat and non-human primate models to …
dopamine agonists may be … Topiramate was shown in rat and non-human primate models to …
Emerging drugs for the treatment of L-DOPA-induced dyskinesia: an update
S AlShimemeri, SH Fox, NP Visanji - Expert Opinion on Emerging …, 2020 - Taylor & Francis
… to reduce dyskinesia in non-human primates with established LID [… A post hoc analysis of
this study showed that compared to … scales, including the commonest used in phase III RCTs of …
this study showed that compared to … scales, including the commonest used in phase III RCTs of …
Pain and dyskinesia in Parkinson's disease may share common pathophysiological mechanisms–An fMRI study
… presentation was repeated for each participant on each session). Analysis was performed with
the FSL Expert Analysis … We found that dyskinetic PD patients had reduced JNP thresholds…
the FSL Expert Analysis … We found that dyskinetic PD patients had reduced JNP thresholds…
Parkinson's Disease in Humans and in Nonhuman Primate Aging and Neurotoxin Models
… PD is envisioned today, review available PD NHP models, … seems to emerge from the
analysis of genes nominated by … of chronic levodopa treatment is dyskinesia, the difficulty or …
analysis of genes nominated by … of chronic levodopa treatment is dyskinesia, the difficulty or …