Marmosets in Neurologic Disease Research: Parkinson's Disease

IH Philippens - The Common Marmoset in Captivity and Biomedical …, 2019 - Elsevier
… Adapted rating scales are developed for MPTP monkeys. Key … This observational scale is
used to quantify dyskinesia in the … , are presented by a robot at different speeds in front of the …

Vector-mediated l-3,4-dihydroxyphenylalanine delivery reverses motor impairments in a primate model of Parkinson's disease

C Rosenblad, Q Li, EY Pioli, S Dovero, ASLM Antunes… - Brain, 2019 - academic.oup.com
… Ever since its introduction 40 years ago l-3,4-… rhesus monkeys, the standard non-human
primate model of Parkinson’s … both a disability rating scale and a dyskinesia rating scale. Twenty-…

[HTML][HTML] Effects of mGluR5 antagonists on Parkinson's patients with L-Dopa-induced dyskinesia: a systematic review and meta-analysis of randomized controlled trials

WW Wang, XR Zhang, ZR Zhang, XS Wang… - Frontiers in Aging …, 2018 - frontiersin.org
… field, a previous study in non-human primates reported that LID was … the quality of evidence
presented in this meta-analysis as low to … These trials lacked detailed data on all scales. …

Experimental animal models of Parkinson's disease: a transition from assessing symptomatology to α-synuclein targeted disease modification

WKD Ko, E Bezard - Experimental neurology, 2017 - Elsevier
analysis in PD patients, where LB formations were found in … of MPTP into old world non-human
primate (nhp) species (… reversed without the induction of dyskinesia, similar to that seen in …

[HTML][HTML] Additive effects of mGluR2 positive allosteric modulation, mGluR2 orthosteric stimulation and 5-HT2AR antagonism on dyskinesia and psychosis-like …

SG Nuara, JC Gourdon, S Maddaford… - … Archives of Pharmacology, 2021 - Springer
… marmoset, a non-human primate with strong predictive … which we performed one-way
analysis of variance (ANOVA) … First, although we mentioned in the introduction that 5-HT 2A R …

Modulation of the 5-HT3 Receptor as a Novel Anti-Dyskinetic Target in Parkinson's Disease

C Kwan - 2018 - papyrus.bib.umontreal.ca
… In contrast, a meta-analysis of six studies found a lower … movement, and dyskinesia is clinically
heterogeneous in presentation and … and human primates do not develop dyskinesia when …

Breathing new life into neurotoxic-based monkey models of Parkinson's disease to study the complex biological interplay between serotonin and dopamine

V Sgambato - Progress in Brain Research, 2021 - Elsevier
system without affecting the remaining DA neurons. The lesion of 5-HT fibers induced by
MDMA altered rigidity and prevented dyskinesia … In non-human primates (NHP), the use of the …

A preclinical study on the combined effects of repeated eltoprazine and preladenant treatment for alleviating L-DOPA-induced dyskinesia in Parkinson's disease

WKD Ko, Q Li, LY Cheng, M Morelli, M Carta… - European Journal of …, 2017 - Elsevier
… to an established non-parametric rating scale for (i) range of … of the treatment days following
post-hoc analysis (P > 0.05). … therapies, the treatment regimen presented in this study show …

Human iPS cell-derived dopaminergic neurons function in a primate Parkinson's disease model

T Kikuchi, A Morizane, D Doi, H Magotani, H Onoe… - Nature, 2017 - nature.com
… behaviour of rat 1 and non-human primate 6 models of PD. … Abnormal behaviour, such as
dyskinesia, was not observed. … through host-derived antigen-presenting cells, we performed …

Evaluation of rhesus macaque models for cerebral palsy

Y Zhu, Y Xiong, J Zhang, H Tong, H Yang, Q Zhu, X Xu… - Brain Sciences, 2022 - mdpi.com
… Animal models, especially non-human primate models, have … to the left or right, dyskinesia,
and motor incoordination. … are usually assessed with clinical rating scales, such as gross and …