… roles in the proliferation, differentiation, survival, migration, … the PKC inhibitor staurosporine
or the NF-κB inhibitor BAY 11-… phenotypes of pancreatic adenocarcinoma cells [251]. PKCζ …

… is a more selective PKC inhibitor compared to staurosporine, … and was found to inhibit
proliferation, induce differentiation, and … PKC412 or CGP 41251) is a staurosporine analog …

… , aiming to discover the selective inhibitors of PKC, mostly … as a PKC inhibitor analogous
to staurosporine, midostaurin … has been reported following kinase neutralization [251]. …

… developed as a small-molecular inhibitor of protein kinase C (PKC) [7]. … also inhibit multiple
class III tyrosine kinases, including vascular endothelial growth factor receptor 2 (VEGFR-2), c…

… selective small molecule modulators, we report in this dissertation the synthesis of a series
of novel carbamate derivatives of … derivatives is hydrophobicity- dependent and inhibition of …

… kinase to bind ATP are in general less selective than allosteric inhibitors which usually show
very high selectivity … of the broad-spectrum protein kinase inhibitor staurosporine, result in a …

… products and methods for finding new compounds which exhibit selective cytotoxicity. In
order to place this work in context, it is necessary to consider how the concept of selective …

… broad, non-selective multikinase inhibitors such as midostaurin and … -staurosporine), a novel
oral protein kinase C inhibitor, … To request a reprint or commercial or derivative permissions …

… , more potent and selective FLT3 inhibitors are also in … Midostaurin (PKC412) is a derivative
of staurosporine (from the … due to its ability to reversibly inhibit protein kinase C (PKC). Drug …

… Staurosporine (STS), a universal kinase inhibitor, exhibits potent activity … of selectivity, which
result in significant side effects (2). To improve the solubility and specificity, STS derivatives …